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Tclin
KCNA3
Potassium voltage-gated channel subfamily A member 3

Protein Summary
Description
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369769
  • ENSP00000358784
  • ENSG00000177272

Symbol
  • HGK5
  • MK3
  • HGK5
  • HLK3
  • PCN3
  • HPCN3
  • KV1.3
  • HUKIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.81
cell type or tissue
0.73
gene perturbation
0.67
tissue sample
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.03   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 709.03   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 356
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
1
1
30.2
monocyte percentage of leukocytes
1
1
1
11.8
monocyte count
1
1
1
7.9
Beta blocking agent use measurement
1
1
1
3.3
electrocardiography
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
30.2
monocyte percentage of leukocytes
1
11.8
monocyte count
1
7.9
Beta blocking agent use measurement
1
3.3
electrocardiography
1
0.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A member 3
VGNC:10674
469412
Macaque
potassium voltage-gated channel subfamily A member 3
702245
Mouse
MGI:96660
16491
Rat
RGD:2951
29731
Dog
potassium voltage-gated channel subfamily A member 3
VGNC:42230
490110
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A member 3
Macaque
potassium voltage-gated channel subfamily A member 3
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A member 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P22001-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (163)
1 – 10 of 163
KCNA6
Tclin
Family:  IC
Novelty:  18.19090909
p_int:  0.999997704
p_ni:  2.65e-7
p_wrong:  0.000002031
Score:  0.56
Data Source:  BioPlex,STRINGDB
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
p_int:  0.999996051
p_ni:  0.000003931
p_wrong:  1.8e-8
Score:  0.373
Data Source:  BioPlex,STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.98
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.979
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.965
Data Source:  STRINGDB
KCNN4
Tchem
Family:  IC
Novelty:  0.00244935
Score:  0.865
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.841
Data Source:  STRINGDB
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
Score:  0.798
Data Source:  STRINGDB
KCNA1
Tclin
Family:  IC
Novelty:  0.00183322
Score:  0.789
Data Source:  STRINGDB
FAU
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
Publication Statistics
PubMed Score  709.03

PubMed score by year
PubTator Score  354.79

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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