You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
TGM2
Protein-glutamine gamma-glutamyltransferase 2

Protein Summary
Description
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361475
  • ENSP00000355330
  • ENSG00000198959

Symbol
  • TGC
  • TG(C)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
gene perturbation
0.98
PubMedID
0.94
small molecule perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2129.93   (req: < 5)
Gene RIFs: 347   (req: <= 3)
Antibodies: 1101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2129.93   (req: >= 5)
Gene RIFs: 347   (req: > 3)
Antibodies: 1101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 196
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (196)
1 – 10 of 196
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
1
1
0
1.1
80.2
heart rate
1
1
1
79.1
electrocardiography
1
1
18
71.9
pulse pressure measurement
1
1
1
48.5
RR interval
1
1
0
6.6
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
0
1.1
80.2
heart rate
1
79.1
electrocardiography
18
71.9
pulse pressure measurement
1
48.5
RR interval
0
6.6
26.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transglutaminase 2
VGNC:6280
469937
Macaque
transglutaminase 2
706777
Mouse
MGI:98731
21817
Rat
RGD:621081
56083
Dog
transglutaminase 2
VGNC:47316
485867
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transglutaminase 2
Macaque
transglutaminase 2
Mouse
Rat
Dog
transglutaminase 2
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21980-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (159)
1 – 10 of 159
FN1
Tchem
Novelty:  0.00003647
p_int:  0.999995834
p_ni:  0.000004166
Score:  0.878
Data Source:  BioPlex,STRINGDB
DCAF15
Tdark
Novelty:  0.13476661
p_int:  0.999986872
p_ni:  0.000013125
p_wrong:  3e-9
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999432153
p_ni:  0.00056721
p_wrong:  6.38e-7
Score:  0.203
Data Source:  BioPlex,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
p_int:  0.999236077
p_ni:  0.000763393
p_wrong:  5.3e-7
Data Source:  BioPlex
BORA
Tbio
Novelty:  0.0374925
p_int:  0.990946672
p_ni:  0.009053247
p_wrong:  8e-8
Data Source:  BioPlex
TIGD5
Tdark
Novelty:  1.93340494
p_int:  0.989390599
p_ni:  0.010609154
p_wrong:  2.47e-7
Data Source:  BioPlex
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.969903683
p_ni:  0.013958914
p_wrong:  0.016137402
Data Source:  BioPlex
MCM8
Tbio
Family:  Enzyme
Novelty:  0.02602136
p_int:  0.968414668
p_ni:  0.031585299
p_wrong:  3.3e-8
Data Source:  BioPlex
ECM1
Tbio
Novelty:  0.00518679
p_int:  0.948765242
p_ni:  0.007973217
p_wrong:  0.043261541
Data Source:  BioPlex
PKN2
Tchem
Family:  Kinase
Novelty:  0.0088412
p_int:  0.941885559
p_ni:  0.058114441
Data Source:  BioPlex
Publication Statistics
PubMed Score  2129.93

PubMed score by year
PubTator Score  1721.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: