You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
COMT
Catechol O-methyltransferase

Protein Summary
Description
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361682
  • ENSP00000354511
  • ENSG00000093010
  • ENST00000403710
  • ENSP00000385917
  • ENST00000406520
  • ENSP00000385150
  • ENST00000407537
  • ENSP00000384654
  • ENST00000449653
  • ENSP00000416778

Symbol
  • HEL-S-98n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.96
biological process
0.91
transcription factor perturbation
0.88
disease
0.83
transcription factor
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4297.04   (req: < 5)
Gene RIFs: 1330   (req: <= 3)
Antibodies: 566   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4297.04   (req: >= 5)
Gene RIFs: 1330   (req: > 3)
Antibodies: 566   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (94)
CHEMBL4438114
Rendered image for CHEMBL4438114
CHEMBL1091204
Rendered image for CHEMBL1091204
CHEMBL1089630
Rendered image for CHEMBL1089630
CHEMBL1091983
Rendered image for CHEMBL1091983
CHEMBL1089504
Rendered image for CHEMBL1089504
CHEMBL4170443
Rendered image for CHEMBL4170443
Protein-Protein Interactions (207)
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.987
Data Source:  STRINGDB
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
Score:  0.986
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.979
Data Source:  STRINGDB
CYP1B1
Tchem
Novelty:  0.00090917
Score:  0.97
Data Source:  STRINGDB
DBH
Tchem
Family:  Enzyme
Novelty:  0.00074741
Score:  0.968
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.967
Data Source:  STRINGDB
PNMT
Tchem
Family:  Enzyme
Novelty:  0.00178141
Score:  0.96
Data Source:  STRINGDB
ADH1B
Tclin
Family:  Enzyme
Novelty:  0.00204308
Score:  0.94
Data Source:  STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.938
Data Source:  STRINGDB
ADH6
Tbio
Family:  Enzyme
Novelty:  0.01102438
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (80)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Dopamine clearance from the synaptic cleft
Reactome
Enzymatic degradation of Dopamine by monoamine oxidase
Reactome
Enzymatic degradation of dopamine by COMT
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Dopamine clearance from the synaptic cleft
Enzymatic degradation of Dopamine by monoamine oxidase
Enzymatic degradation of dopamine by COMT
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
90.4
platelet count
3
3
2
2.1
89.5
platelet crit
2
2
2
88.7
blood metabolite measurement
1
1
2
88
monocyte count
2
2
2
86.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
90.4
platelet count
2
2.1
89.5
platelet crit
2
88.7
blood metabolite measurement
2
88
monocyte count
2
86.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
catechol-O-methyltransferase
VGNC:12831
458655
Mouse
MGI:88470
12846
Rat
RGD:2379
24267
Dog
catechol-O-methyltransferase
VGNC:39501
445450
Pig
catechol-O-methyltransferase
100155530
Species
Name
OMA
EggNOG
Inparanoid
Chimp
catechol-O-methyltransferase
Mouse
Rat
Dog
catechol-O-methyltransferase
Pig
catechol-O-methyltransferase
Publication Statistics
PubMed Score 4297.04
PubMed score by year
PubTator Score 3285.48
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title