You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CD9
CD9 antigen

Protein Summary
Description
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:8478605, PubMed:14575715, PubMed:18541721). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (PubMed:8478605, PubMed:7511626). This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000009180
  • ENSP00000009180
  • ENSG00000010278
  • ENST00000382518
  • ENSP00000371958
  • ENST00000538834
  • ENSP00000496639

Symbol
  • MIC3
  • TSPAN29
  • MIC3
  • MRP-1
  • BTCC-1
  • DRAP-27
  • TSPAN29
  • TSPAN-29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.96
gene perturbation
0.95
PubMedID
0.84
biological term
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.11   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 1674   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.11   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 1674   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
55.1
Pathways (16)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (R-HSA-1300645)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Reactome
Disease
Reactome
Fertilization
Reactome
Hemostasis
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Disease
Fertilization
Hemostasis
Infectious disease
Gene Ontology Terms (27)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (160)
1 – 10 of 160
TSPAN1
Tbio
Novelty: 0.01547855
p_int: 0.99959999
p_ni: 0.000029403
p_wrong: 0.000370607
Score: 0.269
Data Source: BioPlex,STRINGDB
IGSF8
Tbio
Novelty: 0.03016623
p_int: 0.993714698
p_ni: 4.6e-8
p_wrong: 0.006285257
Score: 0.898
Data Source: BioPlex,STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.978
Data Source: STRINGDB
IZUMO1
Tbio
Novelty: 0.01839953
Score: 0.966
Data Source: Reactome,STRINGDB
ITGA6
Tbio
Novelty: 0.00217985
Score: 0.961
Data Source: STRINGDB
IZUMO4
Tdark
Novelty: 0.76836026
Score: 0.942
Data Source: STRINGDB
IZUMO3
Tdark
Novelty: 0.90063897
Score: 0.921
Data Source: STRINGDB
IZUMO2
Tdark
Novelty: 0.04397237
Score: 0.91
Data Source: STRINGDB
PTGFRN
Tbio
Novelty: 0.02271483
Score: 0.904
Data Source: STRINGDB
TSG101
Tbio
Novelty: 0.00211746
Score: 0.879
Data Source: STRINGDB
Publication Statistics
PubMed Score  1050.11

PubMed score by year
PubTator Score  497.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer