Protein Classes
Protein Summary
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
- ENST00000304374
- ENSP00000306129
- ENSG00000169676
- DRD1B
- DRD1L2
- DBDR
- DRD1B
- DRD1L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.96 | ||
drug | 0.91 | ||
ligand (chemical) | 0.89 | ||
virus perturbation | 0.83 | ||
molecular function | 0.67 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.76 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 393 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.76 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 393 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 119
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 16
Approved Drugs (16)
1 – 10 of 16
Active Ligands (119)
1 – 10 of 119
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 2 | 12 | 12 | 99.8 | |||||
uric acid measurement | 1 | 1 | 1 | 72.9 | |||||
viral load | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 12 | 99.8 | |||||
uric acid measurement | 1 | 72.9 | |||||
viral load | 1 | 17.8 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dopamine receptor D5 | VGNC:590 | 473340 | |||||
Macaque | dopamine receptor D5 | 712862 | ||||||
Mouse | MGI:94927 | 13492 | ||||||
Rat | RGD:2523 | 25195 | ||||||
Dog | dopamine receptor D5 | VGNC:40096 | 488824 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dopamine receptor D5 | |||||
Macaque | dopamine receptor D5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dopamine receptor D5 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (30)
Reactome (8)
KEGG (4)
PathwayCommons (16)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Dopamine receptors | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Dopamine receptors | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
Gene Ontology Terms (32)
Functions (4)
Components (5)
Processes (23)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (258)
1 – 10 of 258
ADCY9
Family: Enzyme
Novelty: 0.00744116
Score: 0.964
Data Source: STRINGDB
ADCY2
Family: Enzyme
Novelty: 0.01649836
Score: 0.959
Data Source: STRINGDB
ADCY7
Family: Enzyme
Novelty: 0.00984562
Score: 0.959
Data Source: STRINGDB
ADCY4
Family: Enzyme
Novelty: 0.00465974
Score: 0.958
Data Source: STRINGDB
ADCY5
Family: Enzyme
Novelty: 0.00307839
Score: 0.956
Data Source: STRINGDB
ADCY1
Family: Enzyme
Novelty: 0.01089602
Score: 0.953
Data Source: STRINGDB
NPS
Novelty: 0.00692108
Score: 0.953
Data Source: STRINGDB
ADCY8
Family: Enzyme
Novelty: 0.00510386
Score: 0.952
Data Source: STRINGDB
POMC
Novelty: 0.00002436
Score: 0.951
Data Source: STRINGDB
ADCY6
Family: Enzyme
Novelty: 0.00528765
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score 116.76
PubMed score by year
PubTator Score 124.78
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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