Protein Summary
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
- ENST00000304374
- ENSP00000306129
- ENSG00000169676
- DRD1B
- DRD1L2
- DBDR
- DRD1B
- DRD1L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.96 | ||
drug | 0.91 | ||
ligand (chemical) | 0.89 | ||
virus perturbation | 0.83 | ||
molecular function | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.76 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 393 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.76 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 393 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 119
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 16
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (16)
Active Ligands (119)
Protein-Protein Interactions (258)
Nearest Tclin Targets
Pathways (30)
Reactome (8)
KEGG (4)
PathwayCommons (16)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Dopamine receptors | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Dopamine receptors | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (4)
Components (5)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 2 | 12 | 12 | 99.8 | |||||
uric acid measurement | 1 | 1 | 1 | 72.9 | |||||
viral load | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 12 | 99.8 | |||||
uric acid measurement | 1 | 72.9 | |||||
viral load | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dopamine receptor D5 | VGNC:590 | 473340 | |||||
Macaque | dopamine receptor D5 | 712862 | ||||||
Mouse | MGI:94927 | 13492 | ||||||
Rat | RGD:2523 | 25195 | ||||||
Dog | dopamine receptor D5 | VGNC:40096 | 488824 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dopamine receptor D5 | |||||
Macaque | dopamine receptor D5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dopamine receptor D5 | |||||
Publication Statistics
PubMed Score 116.76
PubMed score by year
PubTator Score 124.78
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (115)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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