Protein Classes
Protein Summary
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attent ...more
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IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1002.59 (req: < 5)
Gene RIFs: 456 (req: <= 3)
Antibodies: 424 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1002.59 (req: >= 5)
Gene RIFs: 456 (req: > 3)
Antibodies: 424 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 40
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1236
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 36
Approved Drugs (36)
1 – 10 of 36
Active Ligands (1236)
1 – 10 of 1236
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dopamine receptor D4 | VGNC:11343 | 449578 | |||||
Macaque | dopamine receptor D4 | 699697 | ||||||
Mouse | MGI:94926 | 13491 | ||||||
Rat | RGD:2522 | 25432 | ||||||
Pig | dopamine receptor D4 | 100512329 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dopamine receptor D4 | |||||
Macaque | dopamine receptor D4 | |||||
Mouse | ||||||
Rat | ||||||
Pig | dopamine receptor D4 | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (31)
Reactome (8)
KEGG (2)
PathwayCommons (15)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Dopamine receptors | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Dopamine receptors | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Gene Ontology Terms (46)
Functions (13)
Components (6)
Processes (27)
Items per page:
10
1 – 10 of 13
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (340)
1 – 10 of 340
CNR1
Family: GPCR
Novelty: 0.00060063
Score: 0.965
Data Source: STRINGDB
PDYN
Novelty: 0.00039564
Score: 0.961
Data Source: STRINGDB
GRM2
Family: GPCR
Novelty: 0.00132156
Score: 0.952
Data Source: STRINGDB
PENK
Novelty: 0.00074167
Score: 0.95
Data Source: STRINGDB
POMC
Novelty: 0.00002436
Score: 0.95
Data Source: STRINGDB
GABBR1
Family: GPCR
Novelty: 0.00086493
Score: 0.95
Data Source: STRINGDB
CNR2
Family: GPCR
Novelty: 0.00215391
Score: 0.949
Data Source: STRINGDB
ADCY1
Family: Enzyme
Novelty: 0.01089602
Score: 0.948
Data Source: STRINGDB
ADCY5
Family: Enzyme
Novelty: 0.00307839
Score: 0.947
Data Source: STRINGDB
NPY
Novelty: 0.00012637
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score 1002.59
PubMed score by year
PubTator Score 1064.72
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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