Protein Summary
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attent ...more
- ENST00000176183
- ENSP00000176183
- ENSG00000069696
- D4DR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
ligand (chemical) | 0.97 | ||
drug | 0.94 | ||
molecular function | 0.88 | ||
disease | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1183.26 (req: < 5)
Gene RIFs: 456 (req: <= 3)
Antibodies: 424 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1183.26 (req: >= 5)
Gene RIFs: 456 (req: > 3)
Antibodies: 424 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 40
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1479
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 37
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (37)
Active Ligands (1479)
Protein-Protein Interactions (340)
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (31)
Reactome (8)
KEGG (2)
PathwayCommons (15)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Dopamine receptors | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Dopamine receptors | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (46)
Functions (13)
Components (6)
Processes (27)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 7 | 0 | 1.2 | 97.5 | |||||
2 | 2 | 0 | 1.2 | 68.8 | |||||
corneal resistance factor | 1 | 1 | 1 | 30.2 | |||||
primary biliary cirrhosis | 1 | 1 | 1 | 21.2 | |||||
1 | 1 | 0 | 1.1 | 19.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 97.5 | |||||
0 | 1.2 | 68.8 | |||||
corneal resistance factor | 1 | 30.2 | |||||
primary biliary cirrhosis | 1 | 21.2 | |||||
0 | 1.1 | 19.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dopamine receptor D4 | VGNC:11343 | 449578 | |||||
Macaque | dopamine receptor D4 | 699697 | ||||||
Mouse | MGI:94926 | 13491 | ||||||
Rat | RGD:2522 | 25432 | ||||||
Pig | dopamine receptor D4 | 100512329 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dopamine receptor D4 | |||||
Macaque | dopamine receptor D4 | |||||
Mouse | ||||||
Rat | ||||||
Pig | dopamine receptor D4 | |||||
Publication Statistics
PubMed Score 1183.26
PubMed score by year
PubTator Score 1064.72
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (663)
GeneRif Annotations (456)
Items per page:
0 of 0
PMID | Year | Title |
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