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Tbio
CD72
B-cell differentiation antigen CD72

Protein Summary
Description
Plays a role in B-cell proliferation and differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259633
  • ENSP00000259633
  • ENSG00000137101
  • ENST00000396757
  • ENSP00000379980

Symbol
  • LYB2
  • CD72b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
kinase perturbation
0.66
cell line
0.61
histone modification site profile
0.61
tissue sample
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.04   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 527   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.04   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 527   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
74.8
lymphocyte count
2
1
2
74.4
leukocyte count
1
1
1
68.6
monocyte count
1
1
1
60.2
platelet crit
1
1
1
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
74.8
lymphocyte count
2
74.4
leukocyte count
1
68.6
monocyte count
1
60.2
platelet crit
1
59.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD72 molecule
VGNC:4653
465075
Macaque
CD72 molecule
100427076
Mouse
MGI:88345
12517
Rat
RGD:1309757
313498
Dog
CD72 molecule
VGNC:38971
481595
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD72 molecule
Macaque
CD72 molecule
Mouse
Rat
Dog
CD72 molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P21854-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
Semaphorin interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Other semaphorin interactions
Semaphorin interactions
Protein-Protein Interactions (53)
1 – 10 of 53
SIGLEC10
Tbio
Novelty:  0.02858542
p_int:  0.999682598
p_ni:  0.000317388
p_wrong:  1.4e-8
Score:  0.608
Data Source:  BioPlex,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.945519171
p_ni:  0.054480829
Score:  0.189
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.808038745
p_ni:  0.191958227
p_wrong:  0.000003028
Score:  0.277
Data Source:  BioPlex,STRINGDB
SEMA4D
Tbio
Novelty:  0.0043592
Score:  0.986
Data Source:  Reactome,STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.969
Data Source:  STRINGDB
BLNK
Tbio
Novelty:  0.00351169
Score:  0.968
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.966
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.964
Data Source:  STRINGDB
PTPN6
Tchem
Family:  Enzyme
Novelty:  0.00535749
Score:  0.963
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.959
Data Source:  STRINGDB
Publication Statistics
PubMed Score  125.04

PubMed score by year
PubTator Score  62.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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