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Tclin
RYR1
Ryanodine receptor 1

Protein Summary
Description
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:11741831, PubMed:16163667). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity). This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malign ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355481
  • ENSP00000347667
  • ENSG00000196218
  • ENST00000359596
  • ENSP00000352608

Symbol
  • RYDR
  • CCO
  • MHS
  • RYR
  • MHS1
  • RYDR
  • SKRR
  • RYR-1
  • PPP1R137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
cellular component
0.91
gene perturbation
0.91
phenotype
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1110.85   (req: < 5)
Gene RIFs: 185   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1110.85   (req: >= 5)
Gene RIFs: 185   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dantrolene
chemical structure image
Pathways (15)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Stimuli-sensing channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Muscle contraction
Stimuli-sensing channels
Gene Ontology Terms (44)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (199)
1 – 10 of 199
FKBP1B
Tchem
Family: Enzyme
Novelty: 0.00640101
Score: 0.992
Data Source: STRINGDB
TRDN
Tbio
Novelty: 0.00251509
Score: 0.99
Data Source: STRINGDB
CACNA1S
Tclin
Family: IC
Novelty: 0.00562075
Score: 0.987
Data Source: STRINGDB
FKBP1A
Tclin
Family: Enzyme
Novelty: 0.00153087
Score: 0.985
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00331843
Score: 0.974
Data Source: STRINGDB
ASPH
Tbio
Family: Enzyme
Novelty: 0.00189873
Score: 0.966
Data Source: STRINGDB
NOS1
Tchem
Family: Enzyme
Novelty: 0.00047449
Score: 0.919
Data Source: STRINGDB
CACNA1C
Tclin
Family: IC
Novelty: 0.00152799
Score: 0.919
Data Source: STRINGDB
STAC3
Tbio
Novelty: 0.00146702
Score: 0.903
Data Source: STRINGDB
CACNA1A
Tchem
Family: IC
Novelty: 0.00078984
Score: 0.897
Data Source: STRINGDB
Publication Statistics
PubMed Score  1110.85

PubMed score by year
PubTator Score  1118.62

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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