Protein Summary
May be involved in collagen fiber assembly. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
- ENST00000331595
- ENSP00000327336
- ENSG00000182492
- SLRR1A
- PGI
- MRLS
- DSPG1
- PG-S1
- SEMDX
- SLRR1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
cellular component | 0.89 | ||
small molecule perturbation | 0.82 | ||
gene perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 856.89 (req: < 5)
Gene RIFs: 101 (req: <= 3)
Antibodies: 371 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 856.89 (req: >= 5)
Gene RIFs: 101 (req: > 3)
Antibodies: 371 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0