Tbio VDAC1 Voltage-dependent anion-selective channel protein 1

Protein Summary

Description

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• P21796
• B3KVK4
• D3DQ93
• Q5FVE7
• Q9UIQ5
• Q9UPL0
• VDAC-1

Gene Name

• VDAC1

Ensembl ID

• ENST00000265333
• ENSP00000265333
• ENSG00000213585
• ENST00000395044
• ENSP00000378484
• ENST00000395047
• ENSP00000378487

Symbol

• VDAC
• PORIN
• VDAC-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
PubMedID	0.88
transcription factor binding site profile	0.88
transcription factor perturbation	0.88
co-expressed gene	0.87

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-dependent Anion-selective Channel Protein 1

Protein / Transporter / Ion Channel / Anion Channel / Voltage-dependent Anion-selective Channel Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1033.32   (req: < 5)

Gene RIFs: 155   (req: <= 3)

Antibodies: 630   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1033.32   (req: >= 5)

Gene RIFs: 155   (req: > 3)

Antibodies: 630   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0