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Tbio
VDAC1
Voltage-dependent anion-selective channel protein 1

Protein Summary
Description
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265333
  • ENSP00000265333
  • ENSG00000213585
  • ENST00000395044
  • ENSP00000378484
  • ENST00000395047
  • ENSP00000378487

Symbol
  • VDAC
  • PORIN
  • VDAC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.88
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
co-expressed gene
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 903.88   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 630   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 903.88   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 630   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
3
71.6
eosinophil percentage of leukocytes
1
2
2
67.4
3
2
0
1.4
66.3
2
2
0
1.1
64.2
serum non-albumin protein measurement
1
2
2
60.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
71.6
eosinophil percentage of leukocytes
2
67.4
0
1.4
66.3
0
1.1
64.2
serum non-albumin protein measurement
2
60.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
voltage dependent anion channel 1
VGNC:8654
745717
Macaque
voltage dependent anion channel 1
710045
Mouse
MGI:106919
22333
Rat
RGD:621575
83529
Dog
voltage dependent anion channel 1
VGNC:48246
474681
Species
Name
OMA
EggNOG
Inparanoid
Chimp
voltage dependent anion channel 1
Macaque
voltage dependent anion channel 1
Mouse
Rat
Dog
voltage dependent anion channel 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21796-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Deubiquitination
Reactome
Macroautophagy
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Deubiquitination
Macroautophagy
Metabolism
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (283)
1 – 10 of 283
APOE
Tbio
Novelty:  0.00005049
p_int:  0.999949506
p_ni:  0.000050386
p_wrong:  1.08e-7
Score:  0.694
Data Source:  BioPlex,STRINGDB
TOMM20
Tbio
Novelty:  0.00275824
Score:  0.994
Data Source:  STRINGDB
VDAC2
Tchem
Novelty:  0.00575936
Score:  0.991
Data Source:  STRINGDB
PPIF
Tchem
Family:  Enzyme
Novelty:  0.00147732
Score:  0.989
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.988
Data Source:  STRINGDB
TOMM40
Tbio
Novelty:  0.0041507
Score:  0.987
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.985
Data Source:  STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
Score:  0.983
Data Source:  STRINGDB
TSPO
Tchem
Novelty:  0.00082324
Score:  0.981
Data Source:  STRINGDB
VDAC3
Tbio
Novelty:  0.0095068
Score:  0.981
Data Source:  STRINGDB
Publication Statistics
PubMed Score  903.88

PubMed score by year
PubTator Score  558.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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