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Tbio
VDAC1
Voltage-dependent anion-selective channel protein 1

Protein Summary
Description
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265333
  • ENSP00000265333
  • ENSG00000213585
  • ENST00000395044
  • ENSP00000378484
  • ENST00000395047
  • ENSP00000378487

Symbol
  • VDAC
  • PORIN
  • VDAC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.88
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
co-expressed gene
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 774.71   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 630   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 774.71   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 630   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Deubiquitination
Reactome
Macroautophagy
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Deubiquitination
Macroautophagy
Metabolism
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (283)
1 – 10 of 283
APOE
Tbio
Novelty: 0.0000621
p_int: 0.999949506
p_ni: 0.000050386
p_wrong: 1.08e-7
Score: 0.694
Data Source: BioPlex,STRINGDB
TOMM20
Tbio
Novelty: 0.00600801
Score: 0.994
Data Source: STRINGDB
VDAC2
Tchem
Novelty: 0.00835655
Score: 0.991
Data Source: STRINGDB
PPIF
Tchem
Family: Enzyme
Novelty: 0.00194474
Score: 0.989
Data Source: STRINGDB
HSPA9
Tbio
Novelty: 0.00133867
Score: 0.988
Data Source: STRINGDB
TOMM40
Tbio
Novelty: 0.00561476
Score: 0.987
Data Source: STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.00712157
Score: 0.985
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.02087315
Score: 0.983
Data Source: STRINGDB
TSPO
Tchem
Novelty: 0.00074285
Score: 0.981
Data Source: STRINGDB
VDAC3
Tbio
Novelty: 0.01448609
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  774.71

PubMed score by year
PubTator Score  558.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer