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Tchem
MDK
Midkine

Protein Summary
Description
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359803
  • ENSP00000352852
  • ENSG00000110492
  • ENST00000395565
  • ENSP00000378932
  • ENST00000395566
  • ENSP00000378933
  • ENST00000395569
  • ENSP00000378936
  • ENST00000405308
  • ENSP00000385451
  • ENST00000407067
  • ENSP00000384034

Symbol
  • MK1
  • NEGF2
  • MK
  • ARAP
  • NEGF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
PubMedID
0.84
biological term
0.82
transcription factor
0.78
biological process
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 743.28   (req: < 5)
Gene RIFs: 129   (req: <= 3)
Antibodies: 529   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 743.28   (req: >= 5)
Gene RIFs: 129   (req: > 3)
Antibodies: 529   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (126)
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
p_int:  0.999983477
p_ni:  0.000016523
Score:  0.546
Data Source:  BioPlex,STRINGDB
CXXC1
Tbio
Family:  Epigenetic
Novelty:  0.01019251
p_int:  0.999953135
p_ni:  0.000046865
Score:  0.513
Data Source:  BioPlex,STRINGDB
TNRC18
Tdark
Novelty:  0.32654022
p_int:  0.999886046
p_ni:  0.000113954
Score:  0.186
Data Source:  BioPlex,STRINGDB
NAF1
Tbio
Novelty:  2.99493689
p_int:  0.99986756
p_ni:  0.000132437
p_wrong:  4e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999622255
p_ni:  0.000377745
Data Source:  BioPlex
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.999579836
p_ni:  0.000420164
Data Source:  BioPlex
UBTF
Tbio
Family:  TF
Novelty:  0.00421069
p_int:  0.999406368
p_ni:  0.000593632
Data Source:  BioPlex
MLLT3
Tchem
Novelty:  0.00361056
p_int:  0.999063395
p_ni:  0.000936605
Data Source:  BioPlex
SRRM2
Tbio
Novelty:  0.03914644
p_int:  0.997421492
p_ni:  0.002578508
Score:  0.226
Data Source:  BioPlex,STRINGDB
CHD9
Tbio
Family:  Epigenetic
Novelty:  0.06234268
p_int:  0.996497911
p_ni:  0.003496929
p_wrong:  0.000005159
Score:  0.71
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
NOTCH2 Activation and Transmission of Signal to the Nucleus (R-HSA-2979096)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
NOTCH2 Activation and Transmission of Signal to the Nucleus
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH2
Name
Explore in Pharos
Explore in Source
NOTCH2 Activation and Transmission of Signal to the Nucleus
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH2
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
2
2
75
3
2
1
1.1
69.6
high density lipoprotein cholesterol measurement
1
1
1
67.3
smoking status measurement
2
2
2
66.6
age at first sexual intercourse measurement
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
75
1
1.1
69.6
high density lipoprotein cholesterol measurement
1
67.3
smoking status measurement
2
66.6
age at first sexual intercourse measurement
1
62.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96949
17242
Rat
RGD:69073
81517
Cow
midkine
VGNC:49556
280852
Pig
midkine
100359358
Anole lizard
midkine
100565875
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
midkine
Pig
midkine
Anole lizard
midkine
Publication Statistics
PubMed Score 743.28
PubMed score by year
PubTator Score 316.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title