Protein Summary
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
- ENST00000359803
- ENSP00000352852
- ENSG00000110492
- ENST00000395565
- ENSP00000378932
- ENST00000395566
- ENSP00000378933
- ENST00000395569
- ENSP00000378936
- ENST00000405308
- ENSP00000385451
- ENST00000407067
- ENSP00000384034
- MK1
- NEGF2
- MK
- ARAP
- NEGF2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.9 | ||
PubMedID | 0.84 | ||
biological term | 0.82 | ||
transcription factor | 0.78 | ||
biological process | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 743.28 (req: < 5)
Gene RIFs: 129 (req: <= 3)
Antibodies: 529 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 743.28 (req: >= 5)
Gene RIFs: 129 (req: > 3)
Antibodies: 529 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (7)
Protein-Protein Interactions (126)
SETD1A
Family: Epigenetic
Novelty: 0.00248544
p_int: 0.999983477
p_ni: 0.000016523
Score: 0.546
Data Source: BioPlex,STRINGDB
CXXC1
Family: Epigenetic
Novelty: 0.01019251
p_int: 0.999953135
p_ni: 0.000046865
Score: 0.513
Data Source: BioPlex,STRINGDB
TNRC18
Novelty: 0.32654022
p_int: 0.999886046
p_ni: 0.000113954
Score: 0.186
Data Source: BioPlex,STRINGDB
NAF1
Novelty: 2.99493689
p_int: 0.99986756
p_ni: 0.000132437
p_wrong: 4e-9
Score: 0.213
Data Source: BioPlex,STRINGDB
SRRM2
Novelty: 0.03914644
p_int: 0.997421492
p_ni: 0.002578508
Score: 0.226
Data Source: BioPlex,STRINGDB
CHD9
Family: Epigenetic
Novelty: 0.06234268
p_int: 0.996497911
p_ni: 0.003496929
p_wrong: 0.000005159
Score: 0.71
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (4)
PathwayCommons (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | NOTCH2 Activation and Transmission of Signal to the Nucleus | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by NOTCH | ||||
Reactome | Signaling by NOTCH2 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
NOTCH2 Activation and Transmission of Signal to the Nucleus | ||||
Signal Transduction | ||||
Signaling by NOTCH | ||||
Signaling by NOTCH2 | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (2)
Components (3)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 2 | 2 | 2 | 75 | |||||
3 | 2 | 1 | 1.1 | 69.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 67.3 | |||||
smoking status measurement | 2 | 2 | 2 | 66.6 | |||||
age at first sexual intercourse measurement | 1 | 1 | 1 | 62.5 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 2 | 75 | |||||
1 | 1.1 | 69.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 67.3 | |||||
smoking status measurement | 2 | 66.6 | |||||
age at first sexual intercourse measurement | 1 | 62.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:96949 | 17242 | ||||||
Rat | RGD:69073 | 81517 | ||||||
Cow | midkine | VGNC:49556 | 280852 | |||||
Pig | midkine | 100359358 | ||||||
Anole lizard | midkine | 100565875 | ||||||
Publication Statistics
PubMed Score 743.28
PubMed score by year
PubTator Score 316.79
PubTator score by year
Related Publications
Text Mined References (159)
GeneRif Annotations (129)
Items per page:
0 of 0
PMID | Year | Title |
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