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Tclin
TBXA2R
Thromboxane A2 receptor

Protein Summary
Description
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375190
  • ENSP00000364336
  • ENSG00000006638
  • ENST00000411851
  • ENSP00000393333

Symbol
  • TXA2-R
  • BDPLT13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.96
histone modification site profile
0.81
kinase
0.72
tissue sample
0.69
biological term
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.37   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.37   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 435
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (221)
1 – 10 of 221
TGM2
Tchem
Family:  Enzyme
Novelty:  0.0005293
Score:  0.986
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.968
Data Source:  Reactome,STRINGDB
LTB4R
Tchem
Family:  GPCR
Novelty:  0.00354427
Score:  0.957
Data Source:  STRINGDB
GNA13
Tbio
Novelty:  0.04149138
Score:  0.955
Data Source:  Reactome,STRINGDB
ADRA1B
Tclin
Family:  GPCR
Novelty:  0.00381271
Score:  0.953
Data Source:  STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.952
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.952
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.95
Data Source:  Reactome,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.949
Data Source:  Reactome,STRINGDB
GRK5
Tchem
Family:  Kinase
Novelty:  0.01108012
Score:  0.948
Data Source:  STRINGDB
Pathways (20)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (12/13) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (12/13) signalling events
G alpha (q) signalling events
GPCR downstream signalling
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
62.6
1
1
0
1.5
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
62.6
0
1.5
39.6
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98496
21390
Rat
RGD:3825
24816
Dog
thromboxane A2 receptor
VGNC:47177
485056
Cow
thromboxane A2 receptor
VGNC:35673
538783
Opossum
thromboxane A2 receptor
100010675
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
thromboxane A2 receptor
Cow
thromboxane A2 receptor
Opossum
thromboxane A2 receptor
Publication Statistics
PubMed Score 148.37
PubMed score by year
PubTator Score 205.93
PubTator score by year
Patents
Patents by year