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Tchem
C5AR1
C5a anaphylatoxin chemotactic receptor 1

Protein Summary
Description
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355085
  • ENSP00000347197
  • ENSG00000197405

Symbol
  • C5AR
  • C5R1
  • C5A
  • C5AR
  • C5R1
  • CD88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.83
protein domain
0.73
tissue sample
0.69
kinase
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 730.51   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 905   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 730.51   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 905   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 182
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
92.6
myeloid white cell count
1
1
1
75.7
appendicular lean mass
1
1
1
59.6
eosinophil count
2
2
2
52
monocyte count
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
92.6
myeloid white cell count
1
75.7
appendicular lean mass
1
59.6
eosinophil count
2
52
monocyte count
1
31.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C5a receptor 1
VGNC:2364
468931
Macaque
complement C5a receptor 1
718056
Mouse
MGI:88232
12273
Rat
RGD:70553
113959
Dog
complement C5a receptor 1
VGNC:38596
442974
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C5a receptor 1
Macaque
complement C5a receptor 1
Mouse
Rat
Dog
complement C5a receptor 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21730-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Complement cascade
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Complement cascade
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (323)
1 – 10 of 323
C5
Tclin
Novelty:  0.00225386
Score:  0.987
Data Source:  Reactome,STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.975
Data Source:  STRINGDB
FPR1
Tchem
Family:  GPCR
Novelty:  0.00256884
Score:  0.957
Data Source:  STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.955
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.949
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.942
Data Source:  STRINGDB
CCL4
Tbio
Novelty:  0.00069278
Score:  0.94
Data Source:  STRINGDB
PMCH
Tbio
Novelty:  0.00600873
Score:  0.938
Data Source:  STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.935
Data Source:  STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
Score:  0.934
Data Source:  STRINGDB
Publication Statistics
PubMed Score  730.51

PubMed score by year
PubTator Score  1571.32

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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