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Tchem
C5AR1
C5a anaphylatoxin chemotactic receptor 1

Protein Summary
Description
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355085
  • ENSP00000347197
  • ENSG00000197405

Symbol
  • C5AR
  • C5R1
  • C5A
  • C5AR
  • C5R1
  • CD88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.83
protein domain
0.73
tissue sample
0.69
kinase
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.08   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 905   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 565.08   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 905   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 164
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (39)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Complement cascade
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Complement cascade
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (323)
1 – 10 of 323
C5
Tclin
Novelty: 0.0030075
Score: 0.987
Data Source: Reactome,STRINGDB
C3
Tbio
Novelty: 0.00025052
Score: 0.975
Data Source: STRINGDB
FPR1
Tchem
Family: GPCR
Novelty: 0.00150161
Score: 0.957
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.955
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.04542644
Score: 0.949
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00039604
Score: 0.942
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00091965
Score: 0.94
Data Source: STRINGDB
PMCH
Tbio
Novelty: 0.005002
Score: 0.938
Data Source: STRINGDB
GNAI3
Tbio
Novelty: 0.03936457
Score: 0.935
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00066136
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  565.08

PubMed score by year
PubTator Score  1571.32

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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