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Tclin
DRD1
D(1A) dopamine receptor

Protein Summary
Description
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393752
  • ENSP00000377353
  • ENSG00000184845

Symbol
  • DADR
  • DRD1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug
1
co-expressed gene
0.97
chemical
0.96
ligand (chemical)
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1677.84   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 613   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1677.84   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 613   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 421
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 29
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (40)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Dopamine receptors
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Dopamine receptors
G alpha (s) signalling events
GPCR downstream signalling
Protein-Protein Interactions (276)
1 – 10 of 276
ADCY9
Tbio
Family: Enzyme
Novelty: 0.0075779
Score: 0.964
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00337351
Score: 0.963
Data Source: STRINGDB
ADCY7
Tbio
Family: Enzyme
Novelty: 0.01085287
Score: 0.96
Data Source: STRINGDB
ADCY2
Tbio
Family: Enzyme
Novelty: 0.01612818
Score: 0.959
Data Source: STRINGDB
ADCY4
Tbio
Family: Enzyme
Novelty: 0.00621745
Score: 0.957
Data Source: STRINGDB
ADCY1
Tchem
Family: Enzyme
Novelty: 0.01107447
Score: 0.957
Data Source: STRINGDB
CRHR1
Tclin
Family: GPCR
Novelty: 0.00121307
Score: 0.956
Data Source: STRINGDB
CALY
Tbio
Novelty: 0.03879728
Score: 0.955
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00011983
Score: 0.955
Data Source: STRINGDB
ADCY8
Tbio
Family: Enzyme
Novelty: 0.00570107
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  1677.84

PubMed score by year
PubTator Score  587.36

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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