Tclin DRD1 D(1A) dopamine receptor

Protein Summary

Description

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21728
• B2RA44
• Q4QRJ0

Gene Name

• DRD1

Ensembl ID

• ENST00000393752
• ENSP00000377353
• ENSG00000184845

Symbol

• DADR
• DRD1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
drug	1
co-expressed gene	0.97
chemical	0.96
ligand (chemical)	0.93

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / D(1a) Dopamine Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Dopamine Receptor / D(1a) Dopamine Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.2   (req: < 5)

Gene RIFs: 187   (req: <= 3)

Antibodies: 613   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.2   (req: >= 5)

Gene RIFs: 187   (req: > 3)

Antibodies: 613   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 519

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 31

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (31)

Explore Approved Drugs

1 – 10 of 31

clozapine

DRD1Tclin GPCR

ANTAGONIST pKi : 8.3

chlorpromazine

DRD1Tclin GPCR

ANTAGONIST pKi : 8.15

olanzapine

DRD1Tclin GPCR

ANTAGONIST pKi : 8.32

amitriptyline

DRD1Tclin GPCR

INHIBITOR pKd : 7.46

thioridazine

DRD1Tclin GPCR

ANTAGONIST pKi : 7.2

risperidone

DRD1Tclin GPCR

ANTAGONIST pKi : 9.36

cyproheptadine

DRD1Tclin GPCR

ANTAGONIST pKi : 10.22

fluphenazine

DRD1Tclin GPCR

ANTAGONIST pKi : 9.27

lisuride

DRD1Tclin GPCR

AGONIST pKi : 8.3

metergoline

DRD1Tclin GPCR

ANTAGONIST pKi : 7.4

Active Ligands (519)

Explore Active Ligands

1 – 10 of 519

CHEMBL4128926

DRD1Tclin GPCR

pKd : 9.92

Serotonin

DRD1Tclin GPCR

pKi : 7.53

Pipamazine

DRD1Tclin GPCR

pKi : 8.19

CHEMBL3217984

DRD1Tclin GPCR

pKi : 7.5

CHEMBL3290012

DRD1Tclin GPCR

pKi : 8.72

CHEMBL194837

DRD1Tclin GPCR

pIC50 : 9.7

butaclamol

DRD1Tclin GPCR

pKi : 8.37

asenapine

DRD1Tclin GPCR

pKi : 8.05

CHEMBL193639

DRD1Tclin GPCR

pKi : 7.14

CHEMBL363581

DRD1Tclin GPCR

pKi : 7.11

Protein-Protein Interactions (276)

Explore Interacting Targets

1 – 10 of 276

• See Interactions on String-DB

ADCY9

Tbio

Family:  Enzyme

Novelty:  0.00744116

Score:  0.964

Data Source:  STRINGDB

ADCY5

Tchem

Family:  Enzyme

Novelty:  0.00307839

Score:  0.963

Data Source:  STRINGDB

ADCY7

Tbio

Family:  Enzyme

Novelty:  0.00984562

Score:  0.96

Data Source:  STRINGDB

ADCY2

Tbio

Family:  Enzyme

Novelty:  0.01649836

Score:  0.959

Data Source:  STRINGDB

ADCY4

Tbio

Family:  Enzyme

Novelty:  0.00465974

Score:  0.957

Data Source:  STRINGDB

ADCY1

Tchem

Family:  Enzyme

Novelty:  0.01089602

Score:  0.957

Data Source:  STRINGDB

CRHR1

Tclin

Family:  GPCR

Novelty:  0.00101773

Score:  0.956

Data Source:  STRINGDB

CALY

Tbio

Novelty:  0.05038488

Score:  0.955

Data Source:  STRINGDB

NPS

Tbio

Novelty:  0.00692108

Score:  0.955

Data Source:  STRINGDB

ADCY8

Tchem

Family:  Enzyme

Novelty:  0.00510386

Score:  0.954

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (40)

Reactome (8)

KEGG (10)

PathwayCommons (16)

WikiPathways (6)

Amine ligand-binding receptors (R-HSA-375280)

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1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amine ligand-binding receptors	42 targets	R-HSA-375280
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	Dopamine receptors	5 targets	R-HSA-390651
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396

Name	Explore in Pharos	Explore in Source
Amine ligand-binding receptors	42 targets	R-HSA-375280
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Dopamine receptors	5 targets	R-HSA-390651
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (65)

Functions (4)

Components (10)

Processes (51)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
dopamine neurotransmitter receptor activity	Inferred from Direct Assay (IDA)	MGI
dopamine neurotransmitter receptor activity, coupled via Gs	Inferred from Direct Assay (IDA)	BHF-UCL
dopamine binding	Inferred from Mutant Phenotype (IMP)	BHF-UCL
G-protein alpha-subunit binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell membrane
Complete proteome
Disulfide bond
Endoplasmic reticulum
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
mortality/aging
muscle phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	dopamine receptor D1		697796
Mouse	dopamine receptor D1	MGI:99578	13488
Rat	dopamine receptor D1	RGD:2518	24316
Dog	dopamine receptor D1	VGNC:40093	489110
Cow	dopamine receptor D1	VGNC:28207	281125

Species	Name	OMA	EggNOG	Inparanoid
Macaque	dopamine receptor D1
Mouse	dopamine receptor D1
Rat	dopamine receptor D1
Dog	dopamine receptor D1
Cow	dopamine receptor D1

Publication Statistics

PubMed Score 500.20

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PubTator Score 587.36

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Related Publications

Text Mined References (270)

GeneRif Annotations (187)

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PMID	Year	Title