Protein Classes
Protein Summary
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 481.74 (req: < 5)
Gene RIFs: 187 (req: <= 3)
Antibodies: 613 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 481.74 (req: >= 5)
Gene RIFs: 187 (req: > 3)
Antibodies: 613 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 421
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 29
Approved Drugs (29)
1 – 10 of 29
Active Ligands (421)
1 – 10 of 421
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | dopamine receptor D1 | 697796 | ||||||
Mouse | MGI:99578 | 13488 | ||||||
Rat | RGD:2518 | 24316 | ||||||
Dog | dopamine receptor D1 | VGNC:40093 | 489110 | |||||
Cow | dopamine receptor D1 | VGNC:28207 | 281125 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | dopamine receptor D1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dopamine receptor D1 | |||||
Cow | dopamine receptor D1 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (40)
Reactome (8)
KEGG (10)
PathwayCommons (16)
WikiPathways (6)
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Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Dopamine receptors | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Dopamine receptors | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
Gene Ontology Terms (65)
Functions (4)
Components (10)
Processes (51)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (276)
1 – 10 of 276
ADCY9
Family: Enzyme
Novelty: 0.00744116
Score: 0.964
Data Source: STRINGDB
ADCY5
Family: Enzyme
Novelty: 0.00307839
Score: 0.963
Data Source: STRINGDB
ADCY7
Family: Enzyme
Novelty: 0.00984562
Score: 0.96
Data Source: STRINGDB
ADCY2
Family: Enzyme
Novelty: 0.01649836
Score: 0.959
Data Source: STRINGDB
ADCY4
Family: Enzyme
Novelty: 0.00465974
Score: 0.957
Data Source: STRINGDB
ADCY1
Family: Enzyme
Novelty: 0.01089602
Score: 0.957
Data Source: STRINGDB
CRHR1
Family: GPCR
Novelty: 0.00101773
Score: 0.956
Data Source: STRINGDB
CALY
Novelty: 0.05038488
Score: 0.955
Data Source: STRINGDB
NPS
Novelty: 0.00692108
Score: 0.955
Data Source: STRINGDB
ADCY8
Family: Enzyme
Novelty: 0.00510386
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score 481.74
PubMed score by year
PubTator Score 587.36
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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