Protein Classes
Protein Summary
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1677.84 (req: < 5)
Gene RIFs: 187 (req: <= 3)
Antibodies: 613 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1677.84 (req: >= 5)
Gene RIFs: 187 (req: > 3)
Antibodies: 613 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 55
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 421
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 29
Approved Drugs (29)
1 – 10 of 29
Active Ligands (421)
1 – 10 of 421
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (40)
Reactome (8)
KEGG (10)
PathwayCommons (16)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Dopamine receptors | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
Dopamine receptors | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
Gene Ontology Terms (65)
Functions (4)
Components (10)
Processes (51)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (276)
1 – 10 of 276
ADCY9
Family: Enzyme
Novelty: 0.0075779
Score: 0.964
Data Source: STRINGDB
ADCY5
Family: Enzyme
Novelty: 0.00337351
Score: 0.963
Data Source: STRINGDB
ADCY7
Family: Enzyme
Novelty: 0.01085287
Score: 0.96
Data Source: STRINGDB
ADCY2
Family: Enzyme
Novelty: 0.01612818
Score: 0.959
Data Source: STRINGDB
ADCY4
Family: Enzyme
Novelty: 0.00621745
Score: 0.957
Data Source: STRINGDB
ADCY1
Family: Enzyme
Novelty: 0.01107447
Score: 0.957
Data Source: STRINGDB
CRHR1
Family: GPCR
Novelty: 0.00121307
Score: 0.956
Data Source: STRINGDB
CALY
Novelty: 0.03879728
Score: 0.955
Data Source: STRINGDB
NPS
Novelty: 0.00011983
Score: 0.955
Data Source: STRINGDB
ADCY8
Family: Enzyme
Novelty: 0.00570107
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score 1677.84
PubMed score by year
PubTator Score 587.36
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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