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Tchem
EPHA1
Ephrin type-A receptor 1

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Rec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275815
  • ENSP00000275815
  • ENSG00000146904
  • ENST00000645847
  • ENSP00000494931
  • ENSG00000284816

Symbol
  • EPH
  • EPHT
  • EPHT1
  • EPH
  • EPHT
  • EPHT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.88
PubMedID
0.84
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.75   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 539   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.75   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (226)
SMG1
Tchem
Family:  Kinase
Novelty:  0.00854339
p_int:  0.999999799
p_ni:  2.01e-7
Score:  0.277
Data Source:  BioPlex,STRINGDB
RELCH
Tdark
Novelty:  0.33696386
p_int:  0.9999997
p_ni:  2.99e-7
Score:  0.162
Data Source:  BioPlex,STRINGDB
USP34
Tbio
Family:  Enzyme
Novelty:  0.16444192
p_int:  0.999997791
p_ni:  0.000002209
Score:  0.159
Data Source:  BioPlex,STRINGDB
SMG9
Tbio
Novelty:  0.03940774
p_int:  0.999987991
p_ni:  5.3e-7
p_wrong:  0.000011479
Score:  0.187
Data Source:  BioPlex,STRINGDB
FAM114A2
Tdark
Novelty:  0.40545319
p_int:  0.999981741
p_ni:  0.00001824
p_wrong:  1.9e-8
Data Source:  BioPlex
DYNC2H1
Tbio
Novelty:  0.01306616
p_int:  0.999980059
p_ni:  0.000019941
Score:  0.188
Data Source:  BioPlex,STRINGDB
DIAPH3
Tbio
Novelty:  0.01165283
p_int:  0.99997974
p_ni:  0.00002026
Score:  0.159
Data Source:  BioPlex,STRINGDB
GSDME
Tbio
Novelty:  0.01231123
p_int:  0.999979601
p_ni:  0.000020399
Data Source:  BioPlex
KIF14
Tbio
Novelty:  0.02313641
p_int:  0.999976879
p_ni:  0.000023121
Score:  0.257
Data Source:  BioPlex,STRINGDB
WDR13
Tbio
Novelty:  0.05397678
p_int:  0.999973179
p_ni:  0.000001948
p_wrong:  0.000024873
Score:  0.2
Data Source:  BioPlex,STRINGDB
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
89.2
serum gamma-glutamyl transferase measurement
2
2
2
89.2
basophil count
3
1
3
85.2
basophil count
3
1
3
85.2
basophil percentage of leukocytes
1
1
1
84.9
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
89.2
serum gamma-glutamyl transferase measurement
2
89.2
basophil count
3
85.2
basophil count
3
85.2
basophil percentage of leukocytes
1
84.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A1
VGNC:14442
463808
Mouse
MGI:107381
13835
Rat
RGD:1304680
312279
Dog
EPH receptor A1
VGNC:40404
482735
Horse
EPH receptor A1
VGNC:17616
100056221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A1
Mouse
Rat
Dog
EPH receptor A1
Horse
EPH receptor A1
Publication Statistics
PubMed Score 660.75
PubMed score by year
PubTator Score 135.90
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title