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Tbio
GPD1
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Protein Summary
Description
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301149
  • ENSP00000301149
  • ENSG00000167588
  • ENST00000548814
  • ENSP00000446768

Symbol
  • GPD-C
  • HTGTI
  • GPDH-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.85
transcription factor perturbation
0.8
disease perturbation
0.79
molecular function
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.86   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.86   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
35.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
35.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycerol-3-phosphate dehydrogenase 1
VGNC:5405
741054
Macaque
glycerol-3-phosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:4455]
Mouse
MGI:95679
14555
Rat
RGD:621381
60666
Dog
glycerol-3-phosphate dehydrogenase 1
VGNC:41376
607942
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycerol-3-phosphate dehydrogenase 1
Macaque
glycerol-3-phosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:4455]
Mouse
Rat
Dog
glycerol-3-phosphate dehydrogenase 1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (155)
1 – 10 of 155
GPD1L
Tbio
Family: Enzyme
Novelty: 0.0169606
p_int: 0.999699366
p_ni: 0.000300634
Score: 0.87
Data Source: BioPlex,STRINGDB
IDH3B
Tbio
Family: Enzyme
Novelty: 0.04326765
p_int: 0.984199064
p_ni: 0.015800936
Score: 0.454
Data Source: BioPlex,STRINGDB
NMD3
Tbio
Novelty: 0.03505289
p_int: 0.971255185
p_ni: 0.02836873
p_wrong: 0.000376085
Score: 0.193
Data Source: BioPlex,STRINGDB
GPD2
Tbio
Family: Enzyme
Novelty: 0.00951917
Score: 0.99
Data Source: STRINGDB
GNPAT
Tchem
Family: Enzyme
Novelty: 0.01255689
Score: 0.951
Data Source: STRINGDB
GPAM
Tbio
Family: Enzyme
Novelty: 0.00973127
Score: 0.948
Data Source: STRINGDB
GNPNAT1
Tbio
Family: Enzyme
Novelty: 0.01739665
Score: 0.929
Data Source: STRINGDB
GPAT2
Tbio
Family: Enzyme
Novelty: 0.03807198
Score: 0.924
Data Source: STRINGDB
GPAT3
Tbio
Family: Enzyme
Novelty: 0.03251979
Score: 0.923
Data Source: STRINGDB
GPAT4
Tbio
Family: Enzyme
Novelty: 0.03409111
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  161.86

PubMed score by year
PubTator Score  67.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer