Tbio GPD1 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

Protein Summary

Description

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• P21695
• F8W1L5
• Q8N1B0
• GPD-C

Gene Name

• GPD1

Ensembl ID

• ENST00000301149
• ENSP00000301149
• ENSG00000167588
• ENST00000548814
• ENSP00000446768

Symbol

• GPD-C
• HTGTI
• GPDH-C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
biological process	0.85
transcription factor perturbation	0.8
disease perturbation	0.79
molecular function	0.73

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Glycerol-3-phosphate Dehydrogenase [Nad(+)], Cytoplasmic

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Glycerol-3-phosphate Dehydrogenase [Nad(+)], Cytoplasmic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 231.07   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 288   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 231.07   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0