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Tchem
TAF1
Transcription initiation factor TFIID subunit 1

Protein Summary
Description
Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276072
  • ENSP00000276072
  • ENSG00000147133
  • ENST00000373790
  • ENSP00000362895
  • ENST00000423759
  • ENSP00000406549

Symbol
  • BA2R
  • CCG1
  • CCGS
  • TAF2A
  • OF
  • XDP
  • BA2R
  • CCG1
  • CCGS
  • DYT3
  • KAT4
  • P250
  • NSCL2
  • TAF2A
  • MRXS33
  • N-TAF1
  • TAFII250
  • DYT3/TAF1
  • TAFII-250
  • TAF(II)250
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
virus
1
interacting protein
0.99
viral protein
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.43   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.43   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 38
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (233)
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999999999
p_ni:  1e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999994
p_ni:  6e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.999999994
p_ni:  6e-9
Data Source:  BioPlex
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
TAF2
Tbio
Novelty:  0.0397428
Score:  0.999
Data Source:  STRINGDB
TAF6
Tbio
Novelty:  0.04357176
Score:  0.999
Data Source:  STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.999
Data Source:  STRINGDB
TAF7
Tbio
Novelty:  0.05316615
Score:  0.999
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.999
Data Source:  STRINGDB
TAF5
Tbio
Novelty:  0.05443551
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (63)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (56)
Find Similar Targets
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
45.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TATA-box binding protein associated factor 1
698800
Mouse
MGI:1336878
270627
Dog
TATA-box binding protein associated factor 1
491950
Horse
TATA-box binding protein associated factor 1
100056106
Cow
TATA-box binding protein associated factor 1
785085
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TATA-box binding protein associated factor 1
Mouse
Dog
TATA-box binding protein associated factor 1
Horse
TATA-box binding protein associated factor 1
Cow
TATA-box binding protein associated factor 1
Publication Statistics
PubMed Score 171.43
PubMed score by year
PubTator Score 227.70
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title