Tchem TAF1 Transcription initiation factor TFIID subunit 1

Protein Summary

Description

Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• P21675
• A5CVC8
• A5CVC9
• A5CVD0
• A5CVD1
• B1Q2X3
• Q59FZ3
• Q6IUZ1
• Q70Q86
• Q70Q87
• Q70T00
• Q70T01
• Q70T02
• Q70T03

Gene Name

• TAF1

Ensembl ID

• ENST00000276072
• ENSP00000276072
• ENSG00000147133
• ENST00000373790
• ENSP00000362895
• ENST00000423759
• ENSP00000406549

Symbol

• BA2R
• CCG1
• CCGS
• TAF2A
• OF
• XDP
• BA2R
• CCG1
• CCGS
• DYT3
• KAT4
• P250
• NSCL2
• TAF2A
• MRXS33
• N-TAF1
• TAFII250
• DYT3/TAF1
• TAFII-250
• TAF(II)250

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	1
virus	1
interacting protein	0.99
viral protein	0.98

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Transcription Initiation Factor Tfiid Subunit 1

Protein / Transferase / Acyltransferase / Transcription Initiation Factor Tfiid Subunit 1

Protein / Transferase / Acetyltransferase / Transcription Initiation Factor Tfiid Subunit 1

Protein / Transcription Factor / Transcription Initiation Factor Tfiid Subunit 1

Protein / Nucleic Acid Binding / Nuclease / Transcription Initiation Factor Tfiid Subunit 1

DTO Classes

Protein / Kinase / Protein Kinase / Atypical Group / Taf1 Family / Transcription Initiation Factor Tfiid Subunit 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.06   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.06   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0