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Tchem
TAF1
Transcription initiation factor TFIID subunit 1

Protein Classes
Protein Summary
Description
Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276072
  • ENSP00000276072
  • ENSG00000147133
  • ENST00000373790
  • ENSP00000362895
  • ENST00000423759
  • ENSP00000406549

Symbol
  • BA2R
  • CCG1
  • CCGS
  • TAF2A
  • OF
  • XDP
  • BA2R
  • CCG1
  • CCGS
  • DYT3
  • KAT4
  • P250
  • NSCL2
  • TAF2A
  • MRXS33
  • N-TAF1
  • TAFII250
  • DYT3/TAF1
  • TAFII-250
  • TAF(II)250
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
virus
1
interacting protein
0.99
viral protein
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.88   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.88   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
BAY-299
chemical structure image
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (63)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Gene Ontology Terms (56)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (233)
1 – 10 of 233
TAF7L
Tbio
Novelty: 0.08132691
p_int: 0.999999999
p_ni: 1e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
TAF12
Tbio
Novelty: 0.04352637
p_int: 0.999999994
p_ni: 6e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
SPATA25
Tbio
Novelty: 0.80142563
p_int: 0.999999994
p_ni: 6e-9
Data Source: BioPlex
TAF8
Tbio
Novelty: 0.01056638
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF2
Tbio
Novelty: 0.0397428
Score: 0.999
Data Source: STRINGDB
TAF6
Tbio
Novelty: 0.04357176
Score: 0.999
Data Source: STRINGDB
TAF11
Tbio
Novelty: 0.10299251
Score: 0.999
Data Source: STRINGDB
TAF7
Tbio
Novelty: 0.05316615
Score: 0.999
Data Source: STRINGDB
TBP
Tbio
Novelty: 0.00034941
Score: 0.999
Data Source: STRINGDB
TAF5
Tbio
Novelty: 0.05443551
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  168.88

PubMed score by year
PubTator Score  227.7

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer