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Tchem
TAF1
Transcription initiation factor TFIID subunit 1

Protein Summary
Description
Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300). Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276072
  • ENSP00000276072
  • ENSG00000147133
  • ENST00000373790
  • ENSP00000362895
  • ENST00000423759
  • ENSP00000406549

Symbol
  • BA2R
  • CCG1
  • CCGS
  • TAF2A
  • OF
  • XDP
  • BA2R
  • CCG1
  • CCGS
  • DYT3
  • KAT4
  • P250
  • NSCL2
  • TAF2A
  • MRXS33
  • N-TAF1
  • TAFII250
  • DYT3/TAF1
  • TAFII-250
  • TAF(II)250
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
virus
1
interacting protein
0.99
viral protein
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.06   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.06   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 43
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0