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Tbio
SAT1
Diamine acetyltransferase 1

Protein Summary
Description
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379270
  • ENSP00000368572
  • ENSG00000130066

Symbol
  • SAT
  • SAT
  • DC21
  • KFSD
  • SSAT
  • KFSDX
  • SSAT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
disease perturbation
0.97
kinase perturbation
0.97
transcription factor perturbation
0.97
gene perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.62   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 482.62   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (64)
1 – 10 of 64
PAOX
Tchem
Family:  Enzyme
Novelty:  0.00905719
Score:  0.99
Data Source:  STRINGDB
ODC1
Tclin
Family:  Enzyme
Novelty:  0.00037968
Score:  0.987
Data Source:  STRINGDB
SMOX
Tbio
Family:  Enzyme
Novelty:  0.0071711
Score:  0.973
Data Source:  STRINGDB
SRM
Tchem
Family:  Enzyme
Novelty:  0.01583759
Score:  0.971
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.953
Data Source:  STRINGDB
ITGA9
Tbio
Novelty:  0.01488635
Score:  0.95
Data Source:  STRINGDB
AGMAT
Tbio
Family:  Enzyme
Novelty:  0.03970349
Score:  0.941
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.909
Data Source:  STRINGDB
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
Score:  0.908
Data Source:  STRINGDB
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
Score:  0.903
Data Source:  STRINGDB
Pathways (15)
Interconversion of polyamines (R-HSA-351200)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of polyamines
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Name
Explore in Pharos
Explore in Source
Interconversion of polyamines
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98233
20229
Rat
RGD:1586174
302642
Dog
spermidine/spermine N1-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10540]
Horse
spermidine/spermine N1-acetyltransferase 1
VGNC:22698
100051982
Cow
spermidine/spermine N1-acetyltransferase 1
VGNC:34296
508861
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
spermidine/spermine N1-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10540]
Horse
spermidine/spermine N1-acetyltransferase 1
Cow
spermidine/spermine N1-acetyltransferase 1
Publication Statistics
PubMed Score 482.62
PubMed score by year
PubTator Score 329.47
PubTator score by year