NT5E
5'-nucleotidase
Protein Summary
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
- ENST00000257770
- ENSP00000257770
- ENSG00000135318
- ENST00000369651
- ENSP00000358665
- NT5
- NTE
- NT
- eN
- NT5
- NTE
- eNT
- CD73
- E5NT
- CALJA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
transcription factor perturbation | 0.98 | ||
small molecule perturbation | 0.93 | ||
gene perturbation | 0.84 | ||
biological process | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1620.27 (req: < 5)
Gene RIFs: 228 (req: <= 3)
Antibodies: 1134 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1620.27 (req: >= 5)
Gene RIFs: 228 (req: > 3)
Antibodies: 1134 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 193
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0