Tchem NT5E 5'-nucleotidase

Protein Classes

PANTHER Classes

Protein / ... / Phosphodiesterase / 5'-Nucleotidase

DTO Classes

Protein / Enzyme / Hydrolase / Phosphodiesterase / 5'-Nucleotidase

Protein Summary

Description

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• P21589
• B3KQI8
• O75520
• Q5W116
• 5'-NT

Gene Name

• NT5E

Ensembl ID

• ENST00000257770
• ENSP00000257770
• ENSG00000135318
• ENST00000369651
• ENSP00000358665

Symbol

• NT5
• NTE
• NT
• eN
• NT5
• NTE
• eNT
• CD73
• E5NT
• CALJA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
transcription factor perturbation	0.98
small molecule perturbation	0.93
gene perturbation	0.84
biological process	0.8

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1275.03   (req: < 5)

Gene RIFs: 111   (req: <= 3)

Antibodies: 1134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1275.03   (req: >= 5)

Gene RIFs: 111   (req: > 3)

Antibodies: 1134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (15)

Explore Active Ligands

1 – 10 of 15

PSB-0963

NT5ETchem Enzyme

Ki : 6.82000017

CHEMBL3800429

NT5ETchem Enzyme

Ki : 7.34

CHEMBL3800324

NT5ETchem Enzyme

Ki : 7.38

CHEMBL3799691

NT5ETchem Enzyme

Ki : 7.57

CHEMBL3798795

NT5ETchem Enzyme

Ki : 7.75

CHEMBL3797302

NT5ETchem Enzyme

Ki : 7.75

CHEMBL3799629

NT5ETchem Enzyme

Ki : 6.47

CHEMBL3798753

NT5ETchem Enzyme

Ki : 7.85

CHEMBL3798620

NT5ETchem Enzyme

Ki : 6.86

CHEMBL3799469

NT5ETchem Enzyme

Ki : 7.04

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	5'-nucleotidase ecto	VGNC:8723	462864
Macaque	5'-nucleotidase ecto		696509
Mouse	5' nucleotidase, ecto	MGI:99782	23959
Rat	5' nucleotidase, ecto	RGD:61956	58813
Dog	5'-nucleotidase ecto	VGNC:44000	474984

Species	Name	OMA	EggNOG	Inparanoid
Chimp	5'-nucleotidase ecto
Macaque	5'-nucleotidase ecto
Mouse	5' nucleotidase, ecto
Rat	5' nucleotidase, ecto
Dog	5'-nucleotidase ecto

Protein Structure (6 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21589-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (78)

Reactome (8)

KEGG (4)

PathwayCommons (10)

WikiPathways (56)

Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of nucleotides	100 targets	R-HSA-15869
Reactome	Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Reactome	Metabolism of water-soluble vitamins and cofactors	122 targets	R-HSA-196849
Reactome	Nicotinate metabolism	31 targets	R-HSA-196807

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of nucleotides	100 targets	R-HSA-15869
Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	122 targets	R-HSA-196849
Nicotinate metabolism	31 targets	R-HSA-196807

Gene Ontology Terms (18)

Functions (3)

Components (7)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
5'-nucleotidase activity	Inferred from Direct Assay (IDA)	CACAO
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
nucleotide binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (304)

Explore Interacting Targets

1 – 10 of 304

• See Interactions on String-DB

USP36

Tbio

Family: Enzyme

Novelty: 0.02779727

p_int: 0.999985355

p_ni: 0.00001448

p_wrong: 1.66e-7

Score: 0.179

Data Source: BioPlex,STRINGDB

USP22

Tbio

Family: Enzyme

Novelty: 0.01416662

p_int: 0.999971211

p_ni: 0.000028787

p_wrong: 1e-9

Data Source: BioPlex

SCAMP1

Tbio

Novelty: 0.03293648

p_int: 0.999952873

p_ni: 0.000047127

Data Source: BioPlex

SLC44A1

Tbio

Family: Transporter

Novelty: 0.01499456

p_int: 0.999952733

p_ni: 0.000047266

p_wrong: 1e-9

Data Source: BioPlex

GLMN

Tbio

Novelty: 0.01940401

p_int: 0.999935766

p_ni: 0.000064234

Data Source: BioPlex

SLC6A8

Tbio

Family: Transporter

Novelty: 0.00332655

p_int: 0.999663585

p_ni: 0.000333686

p_wrong: 0.000002729

Data Source: BioPlex

XPO7

Tbio

Novelty: 0.05412704

p_int: 0.999567385

p_ni: 0.000432615

Data Source: BioPlex

FLVCR1

Tbio

Novelty: 0.02110276

p_int: 0.999532191

p_ni: 0.000467809

Data Source: BioPlex

ARL2

Tbio

Family: Enzyme

Novelty: 0.01989908

p_int: 0.999384455

p_ni: 0.000606283

p_wrong: 0.000009262

Data Source: BioPlex

SLC16A2

Tbio

Family: Transporter

Novelty: 0.00353339

p_int: 0.997955482

p_ni: 0.002042343

p_wrong: 0.000002175

Score: 0.187

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  1275.03

PubMed score by year

Reset Zoom

PubTator Score  1529.15

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
GPI-anchor
Hydrolase

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
craniofacial phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
integument phenotype
renal/urinary system phenotype