You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NT5E
5'-nucleotidase

Protein Summary
Description
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257770
  • ENSP00000257770
  • ENSG00000135318
  • ENST00000369651
  • ENSP00000358665

Symbol
  • NT5
  • NTE
  • NT
  • eN
  • NT5
  • NTE
  • eNT
  • CD73
  • E5NT
  • CALJA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
0.98
small molecule perturbation
0.93
gene perturbation
0.84
biological process
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1338.95   (req: < 5)
Gene RIFs: 111   (req: <= 3)
Antibodies: 1134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1338.95   (req: >= 5)
Gene RIFs: 111   (req: > 3)
Antibodies: 1134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 67
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (67)
Protein-Protein Interactions (304)
USP36
Tbio
Family:  Enzyme
Novelty:  0.02779727
p_int:  0.999985355
p_ni:  0.00001448
p_wrong:  1.66e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.999971211
p_ni:  0.000028787
p_wrong:  1e-9
Data Source:  BioPlex
SCAMP1
Tbio
Novelty:  0.03293648
p_int:  0.999952873
p_ni:  0.000047127
Data Source:  BioPlex
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
p_int:  0.999952733
p_ni:  0.000047266
p_wrong:  1e-9
Data Source:  BioPlex
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999935766
p_ni:  0.000064234
Data Source:  BioPlex
SLC6A8
Tbio
Family:  Transporter
Novelty:  0.00332655
p_int:  0.999663585
p_ni:  0.000333686
p_wrong:  0.000002729
Data Source:  BioPlex
XPO7
Tbio
Novelty:  0.05412704
p_int:  0.999567385
p_ni:  0.000432615
Data Source:  BioPlex
FLVCR1
Tbio
Novelty:  0.02110276
p_int:  0.999532191
p_ni:  0.000467809
Data Source:  BioPlex
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999384455
p_ni:  0.000606283
p_wrong:  0.000009262
Data Source:  BioPlex
SLC16A2
Tbio
Family:  Transporter
Novelty:  0.00353339
p_int:  0.997955482
p_ni:  0.002042343
p_wrong:  0.000002175
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (32)
Explore Nearest Tclin Targets
1 – 5 of 26
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE4B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE4D
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE7B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (78)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
11.5
blood metabolite measurement
1
1
1
11.3
heel bone mineral density
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
11.5
blood metabolite measurement
1
11.3
heel bone mineral density
1
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase ecto
VGNC:8723
462864
Macaque
5'-nucleotidase ecto
696509
Mouse
MGI:99782
23959
Rat
RGD:61956
58813
Dog
5'-nucleotidase ecto
VGNC:44000
474984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase ecto
Macaque
5'-nucleotidase ecto
Mouse
Rat
Dog
5'-nucleotidase ecto
Publication Statistics
PubMed Score 1338.95
PubMed score by year
PubTator Score 1529.15
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title