Protein Summary
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
- ENST00000257770
- ENSP00000257770
- ENSG00000135318
- ENST00000369651
- ENSP00000358665
- NT5
- NTE
- NT
- eN
- NT5
- NTE
- eNT
- CD73
- E5NT
- CALJA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
transcription factor perturbation | 0.98 | ||
small molecule perturbation | 0.93 | ||
gene perturbation | 0.84 | ||
biological process | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1338.95 (req: < 5)
Gene RIFs: 111 (req: <= 3)
Antibodies: 1134 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1338.95 (req: >= 5)
Gene RIFs: 111 (req: > 3)
Antibodies: 1134 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 67
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (67)
Protein-Protein Interactions (304)
USP36
Family: Enzyme
Novelty: 0.02779727
p_int: 0.999985355
p_ni: 0.00001448
p_wrong: 1.66e-7
Score: 0.179
Data Source: BioPlex,STRINGDB
USP22
Family: Enzyme
Novelty: 0.01416662
p_int: 0.999971211
p_ni: 0.000028787
p_wrong: 1e-9
Data Source: BioPlex
SLC44A1
Family: Transporter
Novelty: 0.01499456
p_int: 0.999952733
p_ni: 0.000047266
p_wrong: 1e-9
Data Source: BioPlex
SLC6A8
Family: Transporter
Novelty: 0.00332655
p_int: 0.999663585
p_ni: 0.000333686
p_wrong: 0.000002729
Data Source: BioPlex
ARL2
Family: Enzyme
Novelty: 0.01989908
p_int: 0.999384455
p_ni: 0.000606283
p_wrong: 0.000009262
Data Source: BioPlex
SLC16A2
Family: Transporter
Novelty: 0.00353339
p_int: 0.997955482
p_ni: 0.002042343
p_wrong: 0.000002175
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (32)
Upstream (26)
Downstream (6)
1 – 5 of 26
Pathways (78)
Reactome (8)
KEGG (4)
PathwayCommons (10)
WikiPathways (56)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Reactome | Nicotinate metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Nicotinate metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (3)
Components (7)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CACAO | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
metabolite measurement | 1 | 1 | 1 | 11.5 | |||||
blood metabolite measurement | 1 | 1 | 1 | 11.3 | |||||
heel bone mineral density | 1 | 1 | 1 | 9.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
metabolite measurement | 1 | 11.5 | |||||
blood metabolite measurement | 1 | 11.3 | |||||
heel bone mineral density | 1 | 9.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | 5'-nucleotidase ecto | VGNC:8723 | 462864 | |||||
Macaque | 5'-nucleotidase ecto | 696509 | ||||||
Mouse | MGI:99782 | 23959 | ||||||
Rat | RGD:61956 | 58813 | ||||||
Dog | 5'-nucleotidase ecto | VGNC:44000 | 474984 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | 5'-nucleotidase ecto | |||||
Macaque | 5'-nucleotidase ecto | |||||
Mouse | ||||||
Rat | ||||||
Dog | 5'-nucleotidase ecto | |||||
Publication Statistics
PubMed Score 1338.95
PubMed score by year
PubTator Score 1529.15
PubTator score by year
Related Publications
Text Mined References (150)
GeneRif Annotations (111)
Items per page:
0 of 0
PMID | Year | Title |
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