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Tbio
TNFAIP3
Tumor necrosis factor alpha-induced protein 3

Protein Summary
Description
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237289
  • ENSP00000237289
  • ENSG00000118503
  • ENST00000612899
  • ENSP00000481570

Symbol
  • OTUD7C
  • A20
  • AISBL
  • OTUD7C
  • TNFA1P2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
1
gene perturbation
0.99
transcription factor binding site profile
0.96
molecular function
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.85   (req: < 5)
Gene RIFs: 285   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 393.85   (req: >= 5)
Gene RIFs: 285   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 66
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
3
0
1.8
98.4
5
3
0
1.2
97.6
neutrophil count
1
1
1
68.2
myeloid white cell count
1
1
1
65.3
psoriasis vulgaris
1
1
0
1.2
64.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
98.4
0
1.2
97.6
neutrophil count
1
68.2
myeloid white cell count
1
65.3
psoriasis vulgaris
0
1.2
64.2
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (83)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Death Receptor Signalling
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Death Receptor Signalling
Deubiquitination
Immune System
Innate Immune System
Gene Ontology Terms (72)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (234)
1 – 10 of 234
OTUD5
Tbio
Novelty: 0.0498487
p_int: 0.999997466
p_ni: 0.000001892
p_wrong: 6.42e-7
Score: 0.556
Data Source: BioPlex,STRINGDB
PCDHB5
Tdark
Novelty: 0.49458103
p_int: 0.999793723
p_ni: 0.000206217
p_wrong: 6e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.999545963
p_ni: 0.000304585
p_wrong: 0.000149452
Score: 0.173
Data Source: BioPlex,STRINGDB
SHKBP1
Tbio
Novelty: 0.00235279
p_int: 0.999502219
p_ni: 0.000497781
Score: 0.525
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.999025287
p_ni: 0.000974713
Score: 0.995
Data Source: BioPlex,STRINGDB
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.998890651
p_ni: 0.001109345
p_wrong: 5e-9
Data Source: BioPlex
TBC1D24
Tbio
Novelty: 0.0161631
p_int: 0.998640202
p_ni: 0.000142246
p_wrong: 0.001217552
Score: 0.165
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.993200786
p_ni: 0.006799213
p_wrong: 1e-9
Score: 0.268
Data Source: BioPlex,STRINGDB
KCTD10
Tbio
Novelty: 0.10573929
p_int: 0.964342458
p_ni: 0.035657542
Data Source: BioPlex
AIDA
Tbio
Novelty: 0.7243992
p_int: 0.957896381
p_ni: 0.013190803
p_wrong: 0.028912816
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  393.85

PubMed score by year
PubTator Score  295.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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