Protein Classes
Protein Summary
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
- ENST00000261205
- ENSP00000261205
- ENSG00000067715
- ENST00000393240
- ENSP00000376932
- ENST00000552744
- ENSP00000447575
- SVP65
- SYT
- P65
- SYT
- BAGOS
- SVP65
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.96 | ||
molecular function | 0.94 | ||
trait | 0.93 | ||
gene perturbation | 0.91 | ||
hub protein | 0.82 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 604.26 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 768 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 604.26 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 768 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 3 | 4 | 1 | 6.9 | 96 | ||||
self reported educational attainment | 2 | 2 | 2 | 94.7 | |||||
cognitive function measurement | 3 | 1 | 3 | 93.8 | |||||
mathematical ability | 2 | 2 | 2 | 91.8 | |||||
systolic blood pressure | 1 | 1 | 1 | 51.2 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 1 | 6.9 | 96 | ||||
self reported educational attainment | 2 | 94.7 | |||||
cognitive function measurement | 3 | 93.8 | |||||
mathematical ability | 2 | 91.8 | |||||
systolic blood pressure | 1 | 51.2 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | synaptotagmin 1 | VGNC:5610 | 467079 | |||||
Macaque | synaptotagmin 1 | 695390 | ||||||
Mouse | MGI:99667 | 20979 | ||||||
Rat | RGD:3803 | 25716 | ||||||
Dog | synaptotagmin 1 | VGNC:47040 | 482579 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | synaptotagmin 1 | |||||
Macaque | synaptotagmin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | synaptotagmin 1 | |||||
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (25)
Reactome (21)
KEGG (1)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 21
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acetylcholine Neurotransmitter Release Cycle | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Disease | ||||
Reactome | Dopamine Neurotransmitter Release Cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acetylcholine Neurotransmitter Release Cycle | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Disease | ||||
Dopamine Neurotransmitter Release Cycle | ||||
Gene Ontology Terms (62)
Functions (16)
Components (23)
Processes (23)
Items per page:
10
1 – 10 of 16
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | ParkinsonsUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | ParkinsonsUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | ParkinsonsUK-UCL | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (355)
1 – 10 of 355
SYT2
Novelty: 0.00754735
p_int: 1
Score: 0.928
Data Source: BioPlex,STRINGDB
SYT5
Novelty: 0.03580722
p_int: 1
Score: 0.364
Data Source: BioPlex,STRINGDB
VLDLR
Novelty: 0.00352547
p_int: 0.999999311
p_ni: 6.34e-7
p_wrong: 5.5e-8
Score: 0.256
Data Source: BioPlex,STRINGDB
DGUOK
Family: Kinase
Novelty: 0.00897987
p_int: 0.9998705
p_ni: 0.0001295
Data Source: BioPlex
DNAAF2
Novelty: 0.01254416
p_int: 0.999859725
p_ni: 0.000140275
Data Source: BioPlex
CWC22
Novelty: 0.027689
p_int: 0.999634189
p_ni: 0.000365811
Score: 0.247
Data Source: BioPlex,STRINGDB
NUFIP1
Novelty: 0.11726869
p_int: 0.999605805
p_ni: 0.000394195
Data Source: BioPlex
HAX1
Novelty: 0.00749205
p_int: 0.99943648
p_ni: 0.00056352
Data Source: BioPlex
EIF2B3
Novelty: 0.04963646
p_int: 0.998769377
p_ni: 0.001230623
Data Source: BioPlex
EIF2B5
Novelty: 0.0102209
p_int: 0.994607199
p_ni: 0.005392801
Score: 0.196
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 604.26
PubMed score by year
PubTator Score 511.59
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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