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Tbio
SYT1
Synaptotagmin-1

Protein Summary
Description
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003). The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261205
  • ENSP00000261205
  • ENSG00000067715
  • ENST00000393240
  • ENSP00000376932
  • ENST00000552744
  • ENSP00000447575

Symbol
  • SVP65
  • SYT
  • P65
  • SYT
  • BAGOS
  • SVP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
molecular function
0.94
trait
0.93
gene perturbation
0.91
hub protein
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.29   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 768   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.29   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
4
1
6.9
80.5
self reported educational attainment
2
2
2
77.6
cognitive function measurement
3
1
3
71.3
mathematical ability
2
2
2
70.4
systolic blood pressure
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6.9
80.5
self reported educational attainment
2
77.6
cognitive function measurement
3
71.3
mathematical ability
2
70.4
systolic blood pressure
1
64.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 1
VGNC:5610
467079
Macaque
synaptotagmin 1
695390
Mouse
MGI:99667
20979
Rat
RGD:3803
25716
Dog
synaptotagmin 1
VGNC:47040
482579
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptotagmin 1
Macaque
synaptotagmin 1
Mouse
Rat
Dog
synaptotagmin 1
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21579-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Disease
Reactome
Dopamine Neurotransmitter Release Cycle
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Disease
Dopamine Neurotransmitter Release Cycle
Gene Ontology Terms (62)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (355)
1 – 10 of 355
SYT2
Tbio
Novelty:  0.00754735
p_int:  1
Score:  0.928
Data Source:  BioPlex,STRINGDB
SYT5
Tbio
Novelty:  0.03580722
p_int:  1
Score:  0.364
Data Source:  BioPlex,STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
p_int:  0.999999311
p_ni:  6.34e-7
p_wrong:  5.5e-8
Score:  0.256
Data Source:  BioPlex,STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.9998705
p_ni:  0.0001295
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999859725
p_ni:  0.000140275
Data Source:  BioPlex
CWC22
Tbio
Novelty:  0.027689
p_int:  0.999634189
p_ni:  0.000365811
Score:  0.247
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999605805
p_ni:  0.000394195
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.99943648
p_ni:  0.00056352
Data Source:  BioPlex
EIF2B3
Tbio
Novelty:  0.04963646
p_int:  0.998769377
p_ni:  0.001230623
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.994607199
p_ni:  0.005392801
Score:  0.196
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  616.29

PubMed score by year
PubTator Score  511.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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