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Tclin
CNR1
Cannabinoid receptor 1

Protein Summary
Description
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258, PubMed:21895628, PubMed:27768894). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. At high doses, CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase, decrease in cyclic AMP concentration, inhibition of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369499
  • ENSP00000358511
  • ENSG00000118432
  • ENST00000369501
  • ENSP00000358513
  • ENST00000428600
  • ENSP00000412192
  • ENST00000468898
  • ENSP00000420188
  • ENST00000549890
  • ENSP00000446819

Symbol
  • CNR
  • CB1
  • CNR
  • CB-R
  • CB1A
  • CB1R
  • CANN6
  • CB1K5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
phenotype
0.99
chemical
0.88
microRNA
0.84
disease
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2197.5   (req: < 5)
Gene RIFs: 435   (req: <= 3)
Antibodies: 546   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2197.5   (req: >= 5)
Gene RIFs: 435   (req: > 3)
Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2384
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4