Tbio AGXT Serine--pyruvate aminotransferase

Protein Summary

Description

This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21549
• Q53QU6
• SPT

Gene Name

• AGXT

Ensembl ID

• ENST00000307503
• ENSP00000302620
• ENSG00000172482

Symbol

• AGT1
• SPAT
• AGT
• PH1
• SPT
• AGT1
• SPAT
• TLH6
• AGXT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
molecular function	0.79
biological process	0.72
gene perturbation	0.7
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Transferase / Transaminase / Serine--pyruvate Aminotransferase

DTO Classes

Protein / Enzyme / Transferase / Transaminase / Serine--pyruvate Aminotransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 459.89   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 277   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 459.89   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0