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Tbio
AGXT
Serine--pyruvate aminotransferase

Protein Summary
Description
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307503
  • ENSP00000302620
  • ENSG00000172482

Symbol
  • AGT1
  • SPAT
  • AGT
  • PH1
  • SPT
  • AGT1
  • SPAT
  • TLH6
  • AGXT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.79
biological process
0.72
gene perturbation
0.7
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.6   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.6   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
69.3
body height
1
1
1
40.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
69.3
body height
1
40.5
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alanine--glyoxylate and serine--pyruvate aminotransferase
VGNC:50724
460073
Macaque
alanine-glyoxylate aminotransferase
699941
Mouse
MGI:1329033
11611
Rat
RGD:2073
24792
Dog
serine--pyruvate aminotransferase, mitochondrial
100855679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alanine--glyoxylate and serine--pyruvate aminotransferase
Macaque
alanine-glyoxylate aminotransferase
Mouse
Rat
Dog
serine--pyruvate aminotransferase, mitochondrial
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21549-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Peroxisomal protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Peroxisomal protein import
Protein localization
Gene Ontology Terms (26)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (204)
1 – 10 of 204
GRHPR
Tbio
Family: Enzyme
Novelty: 0.01375508
Score: 0.992
Data Source: STRINGDB
HAO1
Tchem
Family: Enzyme
Novelty: 0.00054723
Score: 0.99
Data Source: STRINGDB
HAO2
Tchem
Family: Enzyme
Novelty: 0.03029536
Score: 0.989
Data Source: STRINGDB
AGXT2
Tbio
Family: Enzyme
Novelty: 0.02018289
Score: 0.984
Data Source: STRINGDB
PIPOX
Tbio
Family: Enzyme
Novelty: 0.04107707
Score: 0.983
Data Source: STRINGDB
HOGA1
Tbio
Family: Enzyme
Novelty: 0.02409935
Score: 0.981
Data Source: STRINGDB
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00234505
Score: 0.964
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.963
Data Source: STRINGDB
DAO
Tchem
Family: Enzyme
Novelty: 0.00414923
Score: 0.957
Data Source: STRINGDB
GLDC
Tbio
Family: Enzyme
Novelty: 0.00900467
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  376.60

PubMed score by year
PubTator Score  1378.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer