You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
S1PR1
Sphingosine 1-phosphate receptor 1

Protein Summary
Description
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305352
  • ENSP00000305416
  • ENSG00000170989
  • ENST00000475289
  • ENSP00000498038
  • ENST00000648480
  • ENSP00000497478
  • ENST00000649383
  • ENSP00000497175

Symbol
  • CHEDG1
  • EDG1
  • EDG1
  • S1P1
  • CD363
  • ECGF1
  • EDG-1
  • CHEDG1
  • D1S3362
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
microRNA
0.79
gene perturbation
0.71
transcription factor binding site profile
0.69
histone modification site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 733.19   (req: < 5)
Gene RIFs: 148   (req: <= 3)
Antibodies: 697   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 733.19   (req: >= 5)
Gene RIFs: 148   (req: > 3)
Antibodies: 697   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1691
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1691)
LPA
Rendered image for LPA
sphingosine 1-phosphate
Rendered image for sphingosine 1-phosphate
CHEMBL3769933
Rendered image for CHEMBL3769933
fingolimod-phosphate
Rendered image for fingolimod-phosphate
Fingolimod phosphate
Rendered image for Fingolimod phosphate
ASP4058
Rendered image for ASP4058
CHEMBL194419
Rendered image for CHEMBL194419
CHEMBL1091103
Rendered image for CHEMBL1091103
Protein-Protein Interactions (325)
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
p_int:  0.99610015
p_ni:  0.00389985
Data Source:  BioPlex
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.993332598
p_ni:  0.006667384
p_wrong:  1.8e-8
Data Source:  BioPlex
HK3
Tbio
Family:  Kinase
Novelty:  0.0151241
p_int:  0.984871049
p_ni:  0.015128951
Score:  0.202
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.98300953
p_ni:  0.01698963
p_wrong:  8.4e-7
Score:  0.945
Data Source:  BioPlex,STRINGDB
GOLPH3L
Tbio
Novelty:  0.30373124
p_int:  0.976189395
p_ni:  0.023771874
p_wrong:  0.000038731
Data Source:  BioPlex
GNAQ
Tbio
Novelty:  0.0008997
p_int:  0.970897618
p_ni:  0.029102364
p_wrong:  1.8e-8
Data Source:  BioPlex
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.961769624
p_ni:  0.038230375
p_wrong:  1e-9
Data Source:  BioPlex
CD47
Tchem
Novelty:  0.00129086
p_int:  0.947436568
p_ni:  0.05254979
p_wrong:  0.000013643
Data Source:  BioPlex
ARL10
Tdark
Family:  Enzyme
Novelty:  1.16329406
p_int:  0.94042715
p_ni:  0.05957285
Data Source:  BioPlex
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.9299486
p_ni:  0.06498903
p_wrong:  0.00506237
Score:  0.909
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
10
16
99.5
lymphocyte percentage of leukocytes
2
6
7
98.5
testosterone measurement
5
3
5
96
eosinophil count
3
5
6
92.2
neutrophil percentage of leukocytes
1
2
2
84.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
16
99.5
lymphocyte percentage of leukocytes
7
98.5
testosterone measurement
5
96
eosinophil count
6
92.2
neutrophil percentage of leukocytes
2
84.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate receptor 1
VGNC:8100
457063
Mouse
MGI:1096355
13609
Rat
RGD:61958
29733
Dog
sphingosine-1-phosphate receptor 1
VGNC:45836
490138
Horse
sphingosine-1-phosphate receptor 1
VGNC:22660
100050049
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sphingosine-1-phosphate receptor 1
Mouse
Rat
Dog
sphingosine-1-phosphate receptor 1
Horse
sphingosine-1-phosphate receptor 1
Publication Statistics
PubMed Score 733.19
PubMed score by year
PubTator Score 376.77
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title