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Tclin
S1PR1
Sphingosine 1-phosphate receptor 1

Protein Summary
Description
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305352
  • ENSP00000305416
  • ENSG00000170989
  • ENST00000475289
  • ENSP00000498038
  • ENST00000648480
  • ENSP00000497478
  • ENST00000649383
  • ENSP00000497175

Symbol
  • CHEDG1
  • EDG1
  • EDG1
  • S1P1
  • CD363
  • ECGF1
  • EDG-1
  • CHEDG1
  • D1S3362
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
microRNA
0.79
gene perturbation
0.71
transcription factor binding site profile
0.69
histone modification site profile
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 703.15   (req: < 5)
Gene RIFs: 148   (req: <= 3)
Antibodies: 697   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 703.15   (req: >= 5)
Gene RIFs: 148   (req: > 3)
Antibodies: 697   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1088
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
5
64.5
monocyte count
1
3
3
57.8
lymphocyte percentage of leukocytes
1
2
2
47.4
monocyte percentage of leukocytes
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
64.5
monocyte count
3
57.8
lymphocyte percentage of leukocytes
2
47.4
monocyte percentage of leukocytes
1
3.9
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (325)
1 – 10 of 325
ACP2
Tbio
Family: Enzyme
Novelty: 0.00355652
p_int: 0.99610015
p_ni: 0.00389985
Data Source: BioPlex
ATP2B3
Tbio
Family: Transporter
Novelty: 0.00901493
p_int: 0.993332598
p_ni: 0.006667384
p_wrong: 1.8e-8
Data Source: BioPlex
HK3
Tbio
Family: Kinase
Novelty: 0.0151241
p_int: 0.984871049
p_ni: 0.015128951
Score: 0.202
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.98300953
p_ni: 0.01698963
p_wrong: 8.4e-7
Score: 0.945
Data Source: BioPlex,STRINGDB
GOLPH3L
Tbio
Novelty: 0.30373124
p_int: 0.976189395
p_ni: 0.023771874
p_wrong: 0.000038731
Data Source: BioPlex
GNAQ
Tbio
Novelty: 0.0008997
p_int: 0.970897618
p_ni: 0.029102364
p_wrong: 1.8e-8
Data Source: BioPlex
ATP12A
Tchem
Family: Transporter
Novelty: 0.00008793
p_int: 0.961769624
p_ni: 0.038230375
p_wrong: 1e-9
Data Source: BioPlex
CD47
Tchem
Novelty: 0.00129086
p_int: 0.947436568
p_ni: 0.05254979
p_wrong: 0.000013643
Data Source: BioPlex
ARL10
Tdark
Family: Enzyme
Novelty: 1.16329406
p_int: 0.94042715
p_ni: 0.05957285
Data Source: BioPlex
GNG5
Tbio
Novelty: 0.1525101
p_int: 0.9299486
p_ni: 0.06498903
p_wrong: 0.00506237
Score: 0.909
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  703.15

PubMed score by year
PubTator Score  376.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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