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Tchem
TACR2
Substance-K receptor

Protein Summary
Description
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373306
  • ENSP00000362403
  • ENSG00000075073

Symbol
  • NK2R
  • NKNAR
  • TAC2R
  • SKR
  • NK2R
  • NKNAR
  • TAC2R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.82
biological process
0.79
ligand (protein)
0.68
virus perturbation
0.59
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 627
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tachykinin receptor 2
VGNC:5800
450506
Macaque
tachykinin receptor 2
711842
Mouse
MGI:98477
21337
Rat
RGD:3812
25007
Dog
tachykinin receptor 2
VGNC:47067
489020
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tachykinin receptor 2
Macaque
tachykinin receptor 2
Mouse
Rat
Dog
tachykinin receptor 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P21452-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (67)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (187)
1 – 10 of 187
TAC1
Tbio
Novelty: 0.00006575
Score: 0.999
Data Source: Reactome,STRINGDB
TAC3
Tchem
Novelty: 0.001685
Score: 0.993
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.965
Data Source: STRINGDB
GNRH1
Tbio
Novelty: 0.00020807
Score: 0.941
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.941
Data Source: STRINGDB
KISS1
Tbio
Novelty: 0.00096537
Score: 0.94
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.929
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.929
Data Source: STRINGDB
QRFP
Tbio
Novelty: 0.02210773
Score: 0.924
Data Source: STRINGDB
GRP
Tbio
Novelty: 0.00034247
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  448.00

PubMed score by year
PubTator Score  216.38

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer