Protein Summary
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
- ENST00000373306
- ENSP00000362403
- ENSG00000075073
- NK2R
- NKNAR
- TAC2R
- SKR
- NK2R
- NKNAR
- TAC2R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.82 | ||
biological process | 0.79 | ||
ligand (protein) | 0.68 | ||
virus perturbation | 0.59 | ||
protein domain | 0.58 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 375.99 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 287 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 375.99 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 287 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 627
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (627)
1 – 10 of 627
Pathways (67)
Reactome (8)
KEGG (2)
WikiPathways (57)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Gene Ontology Terms (20)
Functions (2)
Components (5)
Processes (13)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (187)
1 – 10 of 187
TAC1
Novelty: 0.00007711
Score: 0.999
Data Source: Reactome,STRINGDB
TAC3
Novelty: 0.00210451
Score: 0.993
Data Source: STRINGDB
NPS
Novelty: 0.00011983
Score: 0.965
Data Source: STRINGDB
GNRH1
Novelty: 0.00024998
Score: 0.941
Data Source: STRINGDB
KNG1
Novelty: 0.00008572
Score: 0.941
Data Source: STRINGDB
KISS1
Novelty: 0.00111063
Score: 0.94
Data Source: STRINGDB
CCK
Novelty: 0.00013779
Score: 0.929
Data Source: STRINGDB
NTS
Novelty: 0.00035891
Score: 0.929
Data Source: STRINGDB
QRFP
Novelty: 0.02279173
Score: 0.924
Data Source: STRINGDB
GRP
Novelty: 0.00039263
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score 375.99
PubMed score by year
PubTator Score 216.38
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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