Protein Classes
Protein Summary
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]
- ENST00000373306
- ENSP00000362403
- ENSG00000075073
- NK2R
- NKNAR
- TAC2R
- SKR
- NK2R
- NKNAR
- TAC2R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.82 | ||
biological process | 0.79 | ||
ligand (protein) | 0.68 | ||
virus perturbation | 0.59 | ||
protein domain | 0.58 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 448 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 287 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 448 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 287 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 627
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (627)
1 – 10 of 627
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tachykinin receptor 2 | VGNC:5800 | 450506 | |||||
Macaque | tachykinin receptor 2 | 711842 | ||||||
Mouse | MGI:98477 | 21337 | ||||||
Rat | RGD:3812 | 25007 | ||||||
Dog | tachykinin receptor 2 | VGNC:47067 | 489020 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tachykinin receptor 2 | |||||
Macaque | tachykinin receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tachykinin receptor 2 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (67)
Reactome (8)
KEGG (2)
WikiPathways (57)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Gene Ontology Terms (20)
Functions (2)
Components (5)
Processes (13)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (187)
1 – 10 of 187
TAC1
Novelty: 0.00006575
Score: 0.999
Data Source: Reactome,STRINGDB
TAC3
Novelty: 0.001685
Score: 0.993
Data Source: STRINGDB
NPS
Novelty: 0.00692108
Score: 0.965
Data Source: STRINGDB
GNRH1
Novelty: 0.00020807
Score: 0.941
Data Source: STRINGDB
KNG1
Novelty: 0.00007684
Score: 0.941
Data Source: STRINGDB
KISS1
Novelty: 0.00096537
Score: 0.94
Data Source: STRINGDB
CCK
Novelty: 0.00012268
Score: 0.929
Data Source: STRINGDB
NTS
Novelty: 0.00033201
Score: 0.929
Data Source: STRINGDB
QRFP
Novelty: 0.02210773
Score: 0.924
Data Source: STRINGDB
GRP
Novelty: 0.00034247
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score 448.00
PubMed score by year
PubTator Score 216.38
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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