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Tbio
ABCB4
Phosphatidylcholine translocator ABCB4

Protein Summary
Description
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265723
  • ENSP00000265723
  • ENSG00000005471
  • ENST00000358400
  • ENSP00000351172
  • ENST00000359206
  • ENSP00000352135
  • ENST00000453593
  • ENSP00000392983
  • ENST00000649586
  • ENSP00000496956

Symbol
  • MDR3
  • PGY3
  • GBD1
  • ICP3
  • MDR2
  • MDR3
  • PGY3
  • ABC21
  • MDR2/3
  • PFIC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
gene perturbation
0.8
metabolite
0.78
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1616.11   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1616.11   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0