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Tbio
ABCB4
Phosphatidylcholine translocator ABCB4

Protein Summary
Description
Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265723
  • ENSP00000265723
  • ENSG00000005471
  • ENST00000358400
  • ENSP00000351172
  • ENST00000359206
  • ENSP00000352135
  • ENST00000453593
  • ENSP00000392983
  • ENST00000649586
  • ENSP00000496956

Symbol
  • MDR3
  • PGY3
  • GBD1
  • ICP3
  • MDR2
  • MDR3
  • PGY3
  • ABC21
  • MDR2/3
  • PFIC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
gene perturbation
0.8
metabolite
0.78
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1286.89   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1286.89   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gallstones
1
1
0
1.2
81.9
red blood cell distribution width
3
3
3
76.5
1
2
0
1.5
73.7
serum alanine aminotransferase measurement
1
1
1
49.8
low density lipoprotein cholesterol measurement
3
3
3
45.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gallstones
0
1.2
81.9
red blood cell distribution width
3
76.5
0
1.5
73.7
serum alanine aminotransferase measurement
1
49.8
low density lipoprotein cholesterol measurement
3
45.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily B member 4
VGNC:4241
748364
Macaque
multidrug resistance protein 1 [Source:RefSeq peptide;Acc:NP_001028059]
Mouse
MGI:97569
18670
Dog
ATP binding cassette subfamily B member 4
VGNC:37434
482284
Cow
ATP binding cassette subfamily B member 4
VGNC:53628
100336913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily B member 4
Macaque
multidrug resistance protein 1 [Source:RefSeq peptide;Acc:NP_001028059]
Mouse
Dog
ATP binding cassette subfamily B member 4
Cow
ATP binding cassette subfamily B member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P21439-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1
Disease
Disorders of transmembrane transporters
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (75)
1 – 10 of 75
PPARA
Tclin
Family: NR
Novelty: 0.00017403
Score: 0.935
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.923
Data Source: STRINGDB
FABP1
Tchem
Novelty: 0.00192691
Score: 0.918
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.918
Data Source: STRINGDB
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
Score: 0.908
Data Source: STRINGDB
HELZ2
Tdark
Family: Enzyme
Novelty: 0.1810765
Score: 0.905
Data Source: STRINGDB
TBL1X
Tbio
Novelty: 0.00027212
Score: 0.904
Data Source: STRINGDB
CHD9
Tbio
Family: Epigenetic
Novelty: 0.06234268
Score: 0.904
Data Source: STRINGDB
TBL1XR1
Tbio
Novelty: 0.00503043
Score: 0.903
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  1286.89

PubMed score by year
PubTator Score  648.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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