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Tbio
ACO1
Cytoplasmic aconitate hydratase

Protein Summary
Description
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309951
  • ENSP00000309477
  • ENSG00000122729
  • ENST00000379923
  • ENSP00000369255
  • ENST00000541043
  • ENSP00000438733

Symbol
  • IREB1
  • IRP1
  • ACONS
  • HEL60
  • IREB1
  • IREBP
  • IREBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.99
disease perturbation
0.93
transcription factor perturbation
0.91
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.71   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 528   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.71   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 528   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.981
Data Source:  STRINGDB
IDH1
Tclin
Family:  Enzyme
Novelty:  0.0004831
Score:  0.971
Data Source:  STRINGDB
IDH2
Tclin
Family:  Enzyme
Novelty:  0.00131782
Score:  0.97
Data Source:  STRINGDB
ACLY
Tclin
Family:  Enzyme
Novelty:  0.00114812
Score:  0.958
Data Source:  STRINGDB
IDH3A
Tbio
Family:  Enzyme
Novelty:  0.02027198
Score:  0.957
Data Source:  STRINGDB
IDH3G
Tbio
Family:  Enzyme
Novelty:  0.04861242
Score:  0.955
Data Source:  STRINGDB
IDH3B
Tbio
Family:  Enzyme
Novelty:  0.04326765
Score:  0.955
Data Source:  STRINGDB
GLRX3
Tbio
Novelty:  0.0096265
Score:  0.951
Data Source:  STRINGDB
ACO2
Tbio
Family:  Enzyme
Novelty:  0.00276725
Score:  0.86
Data Source:  STRINGDB
FBXL5
Tbio
Novelty:  0.03103624
Score:  0.819
Data Source:  STRINGDB
Pathways (77)
Iron uptake and transport (R-HSA-917937)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Iron uptake and transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Iron uptake and transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
4
5
83.7
hemoglobin measurement
4
4
5
82
red blood cell density measurement
1
1
1
68.6
erythrocyte count
2
2
2
54.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
5
83.7
hemoglobin measurement
5
82
red blood cell density measurement
1
68.6
erythrocyte count
2
54.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aconitase 1
VGNC:8797
465034
Macaque
aconitase 1
705075
Mouse
MGI:87879
11428
Rat
RGD:2019
50655
Dog
aconitase 1
VGNC:37513
481576
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aconitase 1
Macaque
aconitase 1
Mouse
Rat
Dog
aconitase 1
Publication Statistics
PubMed Score 573.71
PubMed score by year
PubTator Score 250.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title