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Tclin
MAOA
Amine oxidase [flavin-containing] A

Protein Summary
Description
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338702
  • ENSP00000340684
  • ENSG00000189221
  • ENST00000542639
  • ENSP00000440846

Symbol
  • BRNRS
  • MAO-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.99
kinase perturbation
0.97
transcription factor perturbation
0.97
gene perturbation
0.91
pathway
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3310.01   (req: < 5)
Gene RIFs: 388   (req: <= 3)
Antibodies: 421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3310.01   (req: >= 5)
Gene RIFs: 388   (req: > 3)
Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 456
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
monoamine oxidase A
VGNC:14699
743285
Mouse
MGI:96915
17161
Rat
RGD:61898
29253
Dog
monoamine oxidase A
VGNC:42953
403450
Horse
monoamine oxidase A
VGNC:19918
100033867
Species
Name
OMA
EggNOG
Inparanoid
Chimp
monoamine oxidase A
Mouse
Rat
Dog
monoamine oxidase A
Horse
monoamine oxidase A
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21397-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (89)
Amine Oxidase reactions (R-HSA-140179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine Oxidase reactions
Reactome
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Reactome
Biological oxidations
Reactome
Cytokine Signaling in Immune system
Reactome
Defective MAOA causes Brunner syndrome (BRUNS)
Name
Explore in Pharos
Explore in Source
Amine Oxidase reactions
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Biological oxidations
Cytokine Signaling in Immune system
Defective MAOA causes Brunner syndrome (BRUNS)
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (133)
1 – 10 of 133
MAOB
Tclin
Family: Enzyme
Novelty: 0.00030366
p_int: 0.999999666
p_ni: 3.2e-7
p_wrong: 1.3e-8
Score: 0.945
Data Source: BioPlex,STRINGDB
MIEF1
Tbio
Novelty: 0.04096049
p_int: 0.99997423
p_ni: 2.6e-8
p_wrong: 0.000025744
Score: 0.485
Data Source: BioPlex,STRINGDB
COMT
Tclin
Family: Enzyme
Novelty: 0.00025107
Score: 0.987
Data Source: STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.968
Data Source: STRINGDB
DBH
Tchem
Family: Enzyme
Novelty: 0.00074741
Score: 0.957
Data Source: STRINGDB
CYP2D6
Tclin
Family: Enzyme
Novelty: 0.00021853
Score: 0.951
Data Source: STRINGDB
AOC2
Tchem
Family: Enzyme
Novelty: 0.0048282
Score: 0.948
Data Source: STRINGDB
PNMT
Tchem
Family: Enzyme
Novelty: 0.00178141
Score: 0.947
Data Source: STRINGDB
HNMT
Tchem
Family: Enzyme
Novelty: 0.00100341
Score: 0.946
Data Source: STRINGDB
AOC3
Tchem
Family: Enzyme
Novelty: 0.00078739
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  3310.01

PubMed score by year
PubTator Score  1806.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer