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Tbio
FLNA
Filamin-A

Protein Summary
Description
Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encode ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360319
  • ENSP00000353467
  • ENSG00000196924
  • ENST00000369850
  • ENSP00000358866
  • ENST00000422373
  • ENSP00000416926

Symbol
  • FLN
  • FLN1
  • FLN
  • FMD
  • MNS
  • OPD
  • ABPX
  • CSBS
  • CVD1
  • FGS2
  • FLN1
  • NHBP
  • OPD1
  • OPD2
  • XLVD
  • XMVD
  • FLN-A
  • ABP-280
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
protein complex
1
molecular function
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 712.34   (req: < 5)
Gene RIFs: 204   (req: <= 3)
Antibodies: 586   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 712.34   (req: >= 5)
Gene RIFs: 204   (req: > 3)
Antibodies: 586   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
44.9
leukocyte count
1
1
1
42.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
44.9
leukocyte count
1
42.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
filamin A
699524
Mouse
MGI:95556
192176
Rat
RGD:1560614
293860
Dog
filamin A
VGNC:40900
481084
Horse
filamin A
VGNC:18060
100058256
Species
Name
OMA
EggNOG
Inparanoid
Macaque
filamin A
Mouse
Rat
Dog
filamin A
Horse
filamin A
Protein Structure (21 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21333-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (47)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Cytokine Signaling in Immune system
Gene Ontology Terms (76)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (289)
1 – 10 of 289
LAD1
Tbio
Novelty: 0.03059679
p_int: 0.999953904
p_ni: 0.000046096
Data Source: BioPlex
HSPB7
Tbio
Novelty: 0.03344805
p_int: 0.999476352
p_ni: 0.000523648
Score: 0.949
Data Source: BioPlex,STRINGDB
NUDT5
Tbio
Family: Enzyme
Novelty: 0.02550535
p_int: 0.999424629
p_ni: 0.000575372
Data Source: BioPlex
FAM90A1
Tdark
Novelty: 0.95155075
p_int: 0.994417952
p_ni: 0.005582048
Score: 0.234
Data Source: BioPlex,STRINGDB
FBLIM1
Tbio
Novelty: 0.0332985
p_int: 0.976527727
p_ni: 0.023472273
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CAPN6
Tbio
Novelty: 0.04489237
p_int: 0.943511427
p_ni: 0.056488573
Score: 0.329
Data Source: BioPlex,STRINGDB
CARD8
Tbio
Family: Enzyme
Novelty: 0.0146799
p_int: 0.92803243
p_ni: 0.07196757
Data Source: BioPlex
APOH
Tbio
Novelty: 0.00049117
p_int: 0.921516266
p_ni: 0.078483734
Score: 0.485
Data Source: BioPlex,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.06230082
p_int: 0.783698843
p_ni: 0.216301157
Score: 0.355
Data Source: BioPlex,STRINGDB
GP1BA
Tbio
Novelty: 0.00138736
Score: 0.997
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  712.34

PubMed score by year
PubTator Score  464.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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