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Tchem
ATP6V1B2
V-type proton ATPase subunit B, brain isoform

Protein Classes
Protein Summary
Description
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276390
  • ENSP00000276390
  • ENSG00000147416

Symbol
  • ATP6B2
  • VPP3
  • DOOD
  • HO57
  • VATB
  • VPP3
  • Vma2
  • ZLS2
  • ATP6B2
  • ATP6B1B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
molecular function
1
transcription factor perturbation
0.99
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.61   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.61   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
enoxacin
Rendered image for enoxacin
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
6
8
98.6
high density lipoprotein cholesterol measurement
2
8
8
98.3
apolipoprotein A 1 measurement
2
5
5
93.4
apolipoprotein B measurement
1
2
2
45.5
sleep duration
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
98.6
high density lipoprotein cholesterol measurement
8
98.3
apolipoprotein A 1 measurement
5
93.4
apolipoprotein B measurement
2
45.5
sleep duration
1
7.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit B2
VGNC:11958
464033
Macaque
ATPase H+ transporting V1 subunit B2
705605
Mouse
MGI:109618
11966
Rat
RGD:620284
117596
Dog
ATPase H+ transporting V1 subunit B2
VGNC:38277
486137
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase H+ transporting V1 subunit B2
Macaque
ATPase H+ transporting V1 subunit B2
Mouse
Rat
Dog
ATPase H+ transporting V1 subunit B2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P21281-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (104)
1 – 10 of 104
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
p_int:  0.999996342
p_ni:  0.000003658
Score:  0.964
Data Source:  BioPlex,Reactome,STRINGDB
ATP6V1C2
Tbio
Family:  Enzyme
Novelty:  0.07583427
p_int:  0.999972141
p_ni:  0.000027859
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.999723483
p_ni:  0.000276517
Score:  0.999
Data Source:  BioPlex,STRINGDB
TLDC2
Tdark
Novelty:  0.76180627
p_int:  0.963947773
p_ni:  0.036052227
Score:  0.282
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.953497851
p_ni:  0.046502149
Score:  0.994
Data Source:  BioPlex,STRINGDB
ATP6V1A
Tbio
Family:  Enzyme
Novelty:  0.00921474
Score:  0.999
Data Source:  STRINGDB
ATP6V1E1
Tbio
Family:  Enzyme
Novelty:  0.04832113
Score:  0.999
Data Source:  STRINGDB
ATP6V1F
Tbio
Family:  Enzyme
Novelty:  0.07109314
Score:  0.999
Data Source:  STRINGDB
ATP6V1H
Tbio
Family:  Enzyme
Novelty:  0.04269105
Score:  0.999
Data Source:  STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
Score:  0.998
Data Source:  STRINGDB
Publication Statistics
PubMed Score  59.61

PubMed score by year
PubTator Score  9.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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