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Tchem
PTN
Pleiotrophin

Protein Summary
Description
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777). The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348225
  • ENSP00000341170
  • ENSG00000105894

Symbol
  • HBNF1
  • NEGF1
  • HARP
  • HBBM
  • HBNF
  • HBGF8
  • NEGF1
  • OSF-1
  • HB-GAM
  • HBGF-8
  • HBNF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
small molecule perturbation
0.8
transcription factor perturbation
0.8
gene perturbation
0.76
biological term
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 892.4   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 892.4   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (72)
SDC3
Tbio
Novelty:  0.01095269
Score:  0.991
Data Source:  STRINGDB
CTTN
Tbio
Novelty:  0.0017962
Score:  0.93
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.93
Data Source:  STRINGDB
PTPRZ1
Tchem
Family:  Enzyme
Novelty:  0.00518159
Score:  0.922
Data Source:  STRINGDB
ALK
Tclin
Family:  Kinase
Novelty:  0.00022375
Score:  0.861
Data Source:  STRINGDB
SDC1
Tbio
Novelty:  0.00044792
Score:  0.773
Data Source:  STRINGDB
PTPRB
Tchem
Family:  Enzyme
Novelty:  0.00797419
Score:  0.734
Data Source:  STRINGDB
HDGF
Tbio
Family:  Epigenetic
Novelty:  0.00273227
Score:  0.715
Data Source:  STRINGDB
VEGFA
Tclin
Novelty:  0.0000378
Score:  0.685
Data Source:  STRINGDB
MEN1
Tchem
Novelty:  0.00059287
Score:  0.675
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (59)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
6
3
1.1
87.9
self reported educational attainment
4
3
4
81.5
risk-taking behaviour
2
2
2
71.6
1
1
0
1.1
38.2
neuroticism measurement
1
1
0
5.8
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
87.9
self reported educational attainment
4
81.5
risk-taking behaviour
2
71.6
0
1.1
38.2
neuroticism measurement
0
5.8
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleiotrophin
VGNC:4483
463759
Macaque
pleiotrophin
709496
Mouse
MGI:97804
19242
Rat
RGD:3444
24924
Dog
pleiotrophin
VGNC:45160
475509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleiotrophin
Macaque
pleiotrophin
Mouse
Rat
Dog
pleiotrophin
Publication Statistics
PubMed Score 892.40
PubMed score by year
PubTator Score 370.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title