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Tbio
PTN
Pleiotrophin

Protein Summary
Description
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777). The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348225
  • ENSP00000341170
  • ENSG00000105894

Symbol
  • HBNF1
  • NEGF1
  • HARP
  • HBBM
  • HBNF
  • HBGF8
  • NEGF1
  • OSF-1
  • HB-GAM
  • HBGF-8
  • HBNF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
small molecule perturbation
0.8
transcription factor perturbation
0.8
gene perturbation
0.76
biological term
0.75


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 870.05   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 870.05   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleiotrophin
VGNC:4483
463759
Macaque
pleiotrophin
709496
Mouse
MGI:97804
19242
Rat
RGD:3444
24924
Dog
pleiotrophin
VGNC:45160
475509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleiotrophin
Macaque
pleiotrophin
Mouse
Rat
Dog
pleiotrophin
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P21246-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (59)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (72)
1 – 10 of 72
SDC3
Tbio
Novelty: 0.01095269
Score: 0.991
Data Source: STRINGDB
CTTN
Tbio
Novelty: 0.0017962
Score: 0.93
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.93
Data Source: STRINGDB
PTPRZ1
Tbio
Family: Enzyme
Novelty: 0.00518159
Score: 0.922
Data Source: STRINGDB
ALK
Tclin
Family: Kinase
Novelty: 0.00022375
Score: 0.861
Data Source: STRINGDB
SDC1
Tbio
Novelty: 0.00044792
Score: 0.773
Data Source: STRINGDB
PTPRB
Tchem
Family: Enzyme
Novelty: 0.00797419
Score: 0.734
Data Source: STRINGDB
HDGF
Tbio
Family: Epigenetic
Novelty: 0.00273227
Score: 0.715
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.685
Data Source: STRINGDB
MEN1
Tchem
Novelty: 0.00059287
Score: 0.675
Data Source: STRINGDB
Publication Statistics
PubMed Score  870.05

PubMed score by year
PubTator Score  370.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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