You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAL
Myelin and lymphocyte protein

Protein Summary
Description
Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function. The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, Ma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309988
  • ENSP00000310880
  • ENSG00000172005
  • ENST00000349807
  • ENSP00000322860
  • ENST00000353004
  • ENSP00000306568
  • ENST00000354078
  • ENSP00000304924

Symbol
  • MVP17
  • VIP17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
gene perturbation
0.67
cellular component
0.66
PubMedID
0.64
small molecule perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.23   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.23   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
HNF1A
Tbio
Family:  TF
Novelty:  0.00101291
Score:  0.902
Data Source:  STRINGDB
DIAPH1
Tbio
Novelty:  0.0150259
Score:  0.901
Data Source:  STRINGDB
LIMK1
Tchem
Family:  Kinase
Novelty:  0.00349854
Score:  0.901
Data Source:  STRINGDB
ACTA1
Tbio
Novelty:  0.00111813
Score:  0.9
Data Source:  STRINGDB
SRF
Tbio
Family:  TF
Novelty:  0.00088839
Score:  0.9
Data Source:  STRINGDB
PLLP
Tbio
Family:  IC
Novelty:  0.02222236
Score:  0.696
Data Source:  STRINGDB
PMP22
Tbio
Novelty:  0.00256307
Score:  0.674
Data Source:  STRINGDB
MAG
Tchem
Novelty:  0.00085621
Score:  0.632
Data Source:  STRINGDB
NPHP1
Tbio
Novelty:  0.01113034
Score:  0.615
Data Source:  STRINGDB
JPH3
Tbio
Novelty:  0.01661507
Score:  0.579
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mal, T cell differentiation protein
VGNC:484
459398
Macaque
mal, T-cell differentiation protein
703532
Mouse
MGI:892970
17153
Rat
RGD:3037
25263
Dog
mal, T cell differentiation protein
VGNC:42933
403933
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mal, T cell differentiation protein
Macaque
mal, T-cell differentiation protein
Mouse
Rat
Dog
mal, T cell differentiation protein
Publication Statistics
PubMed Score 35.23
PubMed score by year
PubTator Score 120.15
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title