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Tbio
CD247
T-cell surface glycoprotein CD3 zeta chain

Protein Summary
Description
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal l ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000362089
  • ENSP00000354782
  • ENSG00000198821
  • ENST00000392122
  • ENSP00000375969

Symbol
  • CD3Z
  • T3Z
  • TCRZ
  • T3Z
  • CD3H
  • CD3Q
  • CD3Z
  • TCRZ
  • IMD25
  • CD3-ZETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
trait
0.86
tissue sample
0.73
biological term
0.7
phosphatase
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.56   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 1111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.56   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 1111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
96.7
9
6
0
1.1
96.6
Eczema
2
1
0
1.1
93.4
2
1
0
1.2
76
3
2
0
1.1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
96.7
0
1.1
96.6
Eczema
0
1.1
93.4
0
1.2
76
0
1.1
74.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD247 molecule
VGNC:5011
748272
Macaque
CD247 molecule
697814
Mouse
MGI:88334
12503
Rat
RGD:2305
25300
Horse
CD247 molecule
VGNC:16254
100051432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD247 molecule
Macaque
CD247 molecule
Mouse
Rat
Horse
CD247 molecule
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20963-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (43)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Disease
Reactome
Downstream TCR signaling
Reactome
FCGR activation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Disease
Downstream TCR signaling
FCGR activation
Protein-Protein Interactions (221)
1 – 10 of 221
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.998
Data Source: Reactome,STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.997
Data Source: STRINGDB
CD3D
Tclin
Novelty: 0.00510314
Score: 0.995
Data Source: Reactome,STRINGDB
CD3E
Tclin
Novelty: 0.0053855
Score: 0.991
Data Source: Reactome,STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.991
Data Source: Reactome,STRINGDB
CD2
Tclin
Novelty: 0.00037283
Score: 0.991
Data Source: STRINGDB
ITK
Tclin
Family: Kinase
Novelty: 0.00054195
Score: 0.985
Data Source: STRINGDB
CD3G
Tclin
Novelty: 0.00466154
Score: 0.982
Data Source: Reactome,STRINGDB
CD28
Tbio
Novelty: 0.00036482
Score: 0.982
Data Source: STRINGDB
TRAT1
Tbio
Novelty: 0.0015709
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  412.56

PubMed score by year
PubTator Score  274.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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