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Tbio
RASA1
Ras GTPase-activating protein 1

Protein Summary
Description
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274376
  • ENSP00000274376
  • ENSG00000145715
  • ENST00000456692
  • ENSP00000411221
  • ENST00000512763
  • ENSP00000422008
  • ENST00000515800
  • ENSP00000423395

Symbol
  • GAP
  • RASA
  • GAP
  • PKWS
  • RASA
  • p120
  • CMAVM
  • CM-AVM
  • CMAVM1
  • RASGAP
  • p120GAP
  • p120RASGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
hub protein
0.92
disease perturbation
0.9
histone modification site profile
0.85
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.89   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.89   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (194)
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.996
Data Source:  Reactome,STRINGDB
ARHGAP35
Tbio
Family:  Enzyme
Novelty:  0.00970784
Score:  0.989
Data Source:  Reactome,STRINGDB
DOK1
Tbio
Novelty:  0.01976327
Score:  0.979
Data Source:  STRINGDB
DOK2
Tbio
Novelty:  0.02651438
Score:  0.974
Data Source:  STRINGDB
SOCS3
Tbio
Novelty:  0.00106095
Score:  0.969
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.968
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.968
Data Source:  Reactome,STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.964
Data Source:  Reactome,STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.961
Data Source:  STRINGDB
KHDRBS1
Tbio
Novelty:  0.00647929
Score:  0.961
Data Source:  STRINGDB
Pathways (80)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
44.2
1
1
1
28.1
Gleason score measurement
1
1
1
28.1
cancer aggressiveness measurement
1
1
1
28.1
2
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
44.2
1
28.1
Gleason score measurement
1
28.1
cancer aggressiveness measurement
1
28.1
1
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS p21 protein activator 1
VGNC:7143
461762
Macaque
RAS p21 protein activator 1
694085
Mouse
MGI:97860
218397
Rat
RGD:3537
25676
Dog
RAS p21 protein activator 1
VGNC:45359
479158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS p21 protein activator 1
Macaque
RAS p21 protein activator 1
Mouse
Rat
Dog
RAS p21 protein activator 1
Publication Statistics
PubMed Score 246.89
PubMed score by year
PubTator Score 339.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title