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Tbio
RASA1
Ras GTPase-activating protein 1

Protein Summary
Description
Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274376
  • ENSP00000274376
  • ENSG00000145715
  • ENST00000456692
  • ENSP00000411221
  • ENST00000512763
  • ENSP00000422008
  • ENST00000515800
  • ENSP00000423395

Symbol
  • GAP
  • RASA
  • GAP
  • PKWS
  • RASA
  • p120
  • CMAVM
  • CM-AVM
  • CMAVM1
  • RASGAP
  • p120GAP
  • p120RASGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
hub protein
0.92
disease perturbation
0.9
histone modification site profile
0.85
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.18   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.18   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0