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Tbio
AGA
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

Protein Classes
Protein Summary
Description
Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264595
  • ENSP00000264595
  • ENSG00000038002

Symbol
  • GA
  • AGU
  • ASRG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.88
histone modification site profile
0.78
cellular component
0.76
transcription factor binding site profile
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.04   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.04   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aspartylglucosaminidase
VGNC:10815
461616
Macaque
aspartylglucosaminidase
699740
Mouse
MGI:104873
11593
Rat
RGD:1309646
290923
Dog
aspartylglucosaminidase
VGNC:37694
475638
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aspartylglucosaminidase
Macaque
aspartylglucosaminidase
Mouse
Rat
Dog
aspartylglucosaminidase
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (179)
1 – 10 of 179
MOB4
Tbio
Novelty: 0.03238981
p_int: 0.994729012
p_ni: 0.004383292
p_wrong: 0.000887695
Score: 0.519
Data Source: BioPlex,STRINGDB
HBB
Tbio
Novelty: 0.00049683
p_int: 0.983229278
p_ni: 0.016769837
p_wrong: 8.85e-7
Score: 0.193
Data Source: BioPlex,STRINGDB
FBXO6
Tbio
Novelty: 0.02173918
p_int: 0.956316593
p_ni: 0.043681271
p_wrong: 0.000002136
Score: 0.157
Data Source: BioPlex,STRINGDB
HBA1
Tclin
Novelty: 0.00094113
p_int: 0.946693638
p_ni: 0.052827277
p_wrong: 0.000479085
Data Source: BioPlex
ZER1
Tbio
Novelty: 0.02989698
p_int: 0.823515399
p_ni: 0.176484599
p_wrong: 2e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
GCA
Tbio
Novelty: 0.01485875
Score: 0.983
Data Source: STRINGDB
GAA
Tclin
Family: Enzyme
Novelty: 0.0063246
Score: 0.923
Data Source: STRINGDB
GLB1
Tchem
Family: Enzyme
Novelty: 0.00241713
Score: 0.921
Data Source: STRINGDB
HEXB
Tchem
Family: Enzyme
Novelty: 0.0085045
Score: 0.916
Data Source: STRINGDB
FUCA1
Tchem
Family: Enzyme
Novelty: 0.00961721
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.04

PubMed score by year
PubTator Score  121.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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