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Tbio
FLG
Filaggrin

Protein Summary
Description
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368799
  • ENSP00000357789
  • ENSG00000143631

Symbol
  • ATOD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
protein domain
0.85
cellular component
0.68
cell type or tissue
0.65
phenotype
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1433.61   (req: < 5)
Gene RIFs: 286   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1433.61   (req: >= 5)
Gene RIFs: 286   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
3
4
99.7
5
1
0
1.3
88.8
3
1
2
1.2
86.6
age at onset
1
1
1
77.6
childhood onset asthma
1
1
0
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
99.7
0
1.3
88.8
2
1.2
86.6
age at onset
1
77.6
childhood onset asthma
0
2
74
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
filaggrin
VGNC:541
104002779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
filaggrin
Protein Structure (1 Structure, 15 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (149)
1 – 10 of 149
TNFRSF19
Tbio
Novelty: 0.01295599
p_int: 0.998186294
p_ni: 0.001813706
Data Source: BioPlex
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.975707287
p_ni: 0.024292713
Data Source: BioPlex
PI4KA
Tchem
Family: Kinase
Novelty: 0.01701469
p_int: 0.975321724
p_ni: 0.024678276
Data Source: BioPlex
DTL
Tbio
Novelty: 0.01659105
p_int: 0.961189432
p_ni: 0.038810568
Data Source: BioPlex
FTH1
Tbio
Novelty: 0.000863
p_int: 0.959099057
p_ni: 0.040900943
Data Source: BioPlex
CFAP298
Tbio
Novelty: 0.1550579
p_int: 0.912578562
p_ni: 0.087421438
Score: 0.159
Data Source: BioPlex,STRINGDB
KIR3DS1
Tdark
p_int: 0.841034583
p_ni: 0.158965417
Data Source: BioPlex
STK16
Tchem
Family: Kinase
Novelty: 0.01499094
p_int: 0.839456504
p_ni: 0.160543496
Score: 0.188
Data Source: BioPlex,STRINGDB
UCP2
Tbio
Novelty: 0.00083843
p_int: 0.778361634
p_ni: 0.221638365
p_wrong: 1e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
ZSCAN12
Tdark
Family: TF
Novelty: 0.33578207
p_int: 0.750159016
p_ni: 0.249840984
Data Source: BioPlex
Publication Statistics
PubMed Score  1433.61

PubMed score by year
PubTator Score  756.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer