You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MAG
Myelin-associated glycoprotein

Protein Classes
Protein Summary
Description
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361922
  • ENSP00000355234
  • ENSG00000105695
  • ENST00000392213
  • ENSP00000376048
  • ENST00000537831
  • ENSP00000440695

Symbol
  • GMA
  • GMA
  • S-MAG
  • SPG75
  • SIGLEC4A
  • SIGLEC-4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.74
gene perturbation
0.67
cell type or tissue
0.6
disease
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1035.31   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1035.31   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (66)
Axonal growth inhibition (RHOA activation) (R-HSA-193634)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axonal growth inhibition (RHOA activation)
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Death Receptor Signalling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Axonal growth inhibition (RHOA activation)
Basigin interactions
Cell surface interactions at the vascular wall
Death Receptor Signalling
Hemostasis
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (193)
1 – 10 of 193
PLCB3
Tbio
Family: Enzyme
Novelty: 0.01388454
p_int: 0.999958633
p_ni: 0.000034797
p_wrong: 0.000006571
Data Source: BioPlex
EPS8L1
Tbio
Family: Enzyme
Novelty: 0.15959644
p_int: 0.958236664
p_ni: 0.021754234
p_wrong: 0.020009102
Data Source: BioPlex
MARS2
Tbio
Family: Enzyme
Novelty: 0.02533315
p_int: 0.901904158
p_ni: 0.097720166
p_wrong: 0.000375676
Data Source: BioPlex
OMG
Tbio
Novelty: 0.00993333
Score: 0.995
Data Source: STRINGDB
RTN4R
Tbio
Novelty: 0.00196919
Score: 0.991
Data Source: Reactome,STRINGDB
RTN4
Tbio
Novelty: 0.00080371
Score: 0.988
Data Source: STRINGDB
LINGO1
Tbio
Novelty: 0.00778085
Score: 0.978
Data Source: Reactome,STRINGDB
NGFR
Tclin
Novelty: 0.00072052
Score: 0.971
Data Source: Reactome,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.953
Data Source: Reactome,STRINGDB
MBP
Tbio
Novelty: 0.00016333
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  1035.31

PubMed score by year
PubTator Score  611.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: