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Tchem
MAG
Myelin-associated glycoprotein

Protein Summary
Description
Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361922
  • ENSP00000355234
  • ENSG00000105695
  • ENST00000392213
  • ENSP00000376048
  • ENST00000537831
  • ENSP00000440695

Symbol
  • GMA
  • GMA
  • S-MAG
  • SPG75
  • SIGLEC4A
  • SIGLEC-4A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.74
gene perturbation
0.67
cell type or tissue
0.6
disease
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1045.94   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1045.94   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Protein-Protein Interactions (193)
1 – 10 of 193
PLCB3
Tbio
Family:  Enzyme
Novelty:  0.01388454
p_int:  0.999958633
p_ni:  0.000034797
p_wrong:  0.000006571
Data Source:  BioPlex
EPS8L1
Tbio
Family:  Enzyme
Novelty:  0.15959644
p_int:  0.958236664
p_ni:  0.021754234
p_wrong:  0.020009102
Data Source:  BioPlex
MARS2
Tbio
Family:  Enzyme
Novelty:  0.02533315
p_int:  0.901904158
p_ni:  0.097720166
p_wrong:  0.000375676
Data Source:  BioPlex
OMG
Tbio
Novelty:  0.00993333
Score:  0.995
Data Source:  STRINGDB
RTN4R
Tbio
Novelty:  0.00196919
Score:  0.991
Data Source:  Reactome,STRINGDB
RTN4
Tbio
Novelty:  0.00080371
Score:  0.988
Data Source:  STRINGDB
LINGO1
Tbio
Novelty:  0.00778085
Score:  0.978
Data Source:  Reactome,STRINGDB
NGFR
Tclin
Novelty:  0.00072052
Score:  0.971
Data Source:  Reactome,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.953
Data Source:  Reactome,STRINGDB
MBP
Tbio
Novelty:  0.00016333
Score:  0.944
Data Source:  STRINGDB
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
5
7
92.3
reticulocyte measurement
3
2
3
83.3
reticulocyte count
6
2
6
82.8
mean corpuscular hemoglobin concentration
1
1
1
73.5
red blood cell density measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
92.3
reticulocyte measurement
3
83.3
reticulocyte count
6
82.8
mean corpuscular hemoglobin concentration
1
73.5
red blood cell density measurement
1
53.7
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myelin associated glycoprotein
VGNC:11176
100613667
Macaque
myelin associated glycoprotein
718575
Mouse
MGI:96912
17136
Rat
RGD:3035
29409
Dog
myelin associated glycoprotein
VGNC:42923
611884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myelin associated glycoprotein
Macaque
myelin associated glycoprotein
Mouse
Rat
Dog
myelin associated glycoprotein
Publication Statistics
PubMed Score 1045.94
PubMed score by year
PubTator Score 611.68
PubTator score by year