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Tbio
COL5A1
Collagen alpha-1(V) chain

Protein Summary
Description
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371817
  • ENSP00000360882
  • ENSG00000130635
  • ENST00000618395
  • ENSP00000481360

Symbol
  • EDSC
  • EDSCL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
PubMedID
0.91
small molecule perturbation
0.8
molecular function
0.76
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.67   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.67   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
2
0
2367
79.7
corneal topography
1
1
1
64.6
eye measurement
1
1
1
33.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2367
79.7
corneal topography
1
64.6
eye measurement
1
33.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88457
12831
Rat
RGD:70920
85490
Dog
collagen type V alpha 1 chain
VGNC:51943
480684
Horse
collagen type V alpha 1 chain
VGNC:16744
100069057
Pig
collagen type V alpha 1 chain
397533
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
collagen type V alpha 1 chain
Horse
collagen type V alpha 1 chain
Pig
collagen type V alpha 1 chain
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (29)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (167)
1 – 10 of 167
LAIR2
Tbio
Novelty: 0.06117644
p_int: 0.999999995
p_ni: 5e-9
Data Source: BioPlex
COL8A2
Tbio
Novelty: 0.01672103
p_int: 0.999999863
p_ni: 1.32e-7
p_wrong: 5e-9
Score: 0.939
Data Source: BioPlex,STRINGDB
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.99999971
p_ni: 2.9e-7
Score: 0.971
Data Source: BioPlex,STRINGDB
PTPN2
Tchem
Family: Enzyme
Novelty: 0.00372891
p_int: 0.999994591
p_ni: 0.000005125
p_wrong: 2.85e-7
Score: 0.455
Data Source: BioPlex,STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
p_int: 0.99998814
p_ni: 0.000011821
p_wrong: 3.9e-8
Score: 0.421
Data Source: BioPlex,STRINGDB
C1QTNF2
Tbio
Novelty: 0.18607978
p_int: 0.999926495
p_ni: 0.000043746
p_wrong: 0.000029758
Score: 0.324
Data Source: BioPlex,STRINGDB
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
p_int: 0.993727212
p_ni: 0.000010308
p_wrong: 0.006262479
Score: 0.804
Data Source: BioPlex,STRINGDB
PRSS23
Tbio
Family: Enzyme
Novelty: 0.12685614
p_int: 0.943247269
p_ni: 0.000159095
p_wrong: 0.056593635
Score: 0.322
Data Source: BioPlex,STRINGDB
COL6A2
Tbio
Novelty: 0.01275082
Score: 0.991
Data Source: STRINGDB
COL6A1
Tbio
Novelty: 0.00644855
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  199.67

PubMed score by year
PubTator Score  144.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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