COL5A1
Collagen alpha-1(V) chain
Protein Summary
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing o ...more
- ENST00000371817
- ENSP00000360882
- ENSG00000130635
- ENST00000618395
- ENSP00000481360
- EDSC
- EDSCL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.96 | ||
PubMedID | 0.91 | ||
small molecule perturbation | 0.8 | ||
molecular function | 0.76 | ||
disease perturbation | 0.74 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 199.67 (req: < 5)
Gene RIFs: 64 (req: <= 3)
Antibodies: 405 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 199.67 (req: >= 5)
Gene RIFs: 64 (req: > 3)
Antibodies: 405 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
central corneal thickness | 2 | 2 | 0 | 2367 | 79.7 | ||||
corneal topography | 1 | 1 | 1 | 64.6 | |||||
eye measurement | 1 | 1 | 1 | 33.4 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
central corneal thickness | 0 | 2367 | 79.7 | ||||
corneal topography | 1 | 64.6 | |||||
eye measurement | 1 | 33.4 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:88457 | 12831 | ||||||
Rat | RGD:70920 | 85490 | ||||||
Dog | collagen type V alpha 1 chain | VGNC:51943 | 480684 | |||||
Horse | collagen type V alpha 1 chain | VGNC:16744 | 100069057 | |||||
Pig | collagen type V alpha 1 chain | 397533 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | collagen type V alpha 1 chain | |||||
Horse | collagen type V alpha 1 chain | |||||
Pig | collagen type V alpha 1 chain | |||||
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (5)
KEGG (1)
PathwayCommons (6)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen chain trimerization | ||||
Reactome | Collagen formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen biosynthesis and modifying enzymes | ||||
Collagen chain trimerization | ||||
Collagen formation | ||||
Extracellular matrix organization | ||||
Gene Ontology Terms (29)
Functions (7)
Components (7)
Processes (15)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (167)
1 – 10 of 167
LAIR2
Novelty: 0.06117644
p_int: 0.999999995
p_ni: 5e-9
Data Source: BioPlex
COL8A2
Novelty: 0.01672103
p_int: 0.999999863
p_ni: 1.32e-7
p_wrong: 5e-9
Score: 0.939
Data Source: BioPlex,STRINGDB
PLOD1
Family: Enzyme
Novelty: 0.00905345
p_int: 0.99999971
p_ni: 2.9e-7
Score: 0.971
Data Source: BioPlex,STRINGDB
PTPN2
Family: Enzyme
Novelty: 0.00372891
p_int: 0.999994591
p_ni: 0.000005125
p_wrong: 2.85e-7
Score: 0.455
Data Source: BioPlex,STRINGDB
MMP9
Family: Enzyme
Novelty: 0.00008645
p_int: 0.99998814
p_ni: 0.000011821
p_wrong: 3.9e-8
Score: 0.421
Data Source: BioPlex,STRINGDB
C1QTNF2
Novelty: 0.18607978
p_int: 0.999926495
p_ni: 0.000043746
p_wrong: 0.000029758
Score: 0.324
Data Source: BioPlex,STRINGDB
MMP2
Family: Enzyme
Novelty: 0.00012762
p_int: 0.993727212
p_ni: 0.000010308
p_wrong: 0.006262479
Score: 0.804
Data Source: BioPlex,STRINGDB
PRSS23
Family: Enzyme
Novelty: 0.12685614
p_int: 0.943247269
p_ni: 0.000159095
p_wrong: 0.056593635
Score: 0.322
Data Source: BioPlex,STRINGDB
COL6A2
Novelty: 0.01275082
Score: 0.991
Data Source: STRINGDB
COL6A1
Novelty: 0.00644855
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score 199.67
PubMed score by year
PubTator Score 144.52
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword