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Tbio
CYP2A7
Cytochrome P450 2A7

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301146
  • ENSP00000301146
  • ENSG00000198077

Symbol
  • CPA7
  • CPAD
  • CYP2A
  • CYPIIA7
  • P450-IIA4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
cell type or tissue
0.68
cellular component
0.62
cell line
0.6
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.02   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.02   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking behavior
1
1
1
73.3
nicotine metabolite ratio
1
1
1
73.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking behavior
1
73.3
nicotine metabolite ratio
1
73.3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P20853-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
CYP2E1 reactions
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Fatty acids
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
CYP2E1 reactions
Cytochrome P450 - arranged by substrate type
Fatty acids
Metabolism
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (31)
1 – 10 of 31
CYP2A6
Tchem
Novelty: 0.00105285
p_int: 1
Score: 0.943
Data Source: BioPlex,STRINGDB
CYP2A13
Tbio
Novelty: 0.00697238
p_int: 1
Score: 0.783
Data Source: BioPlex,STRINGDB
PPIG
Tchem
Family: Enzyme
Novelty: 0.00014569
Score: 0.681
Data Source: STRINGDB
APOC2
Tbio
Novelty: 0.0015496
Score: 0.649
Data Source: STRINGDB
CPA5
Tbio
Family: Enzyme
Novelty: 0.0516555
Score: 0.485
Data Source: STRINGDB
CPA1
Tchem
Family: Enzyme
Novelty: 0.00601525
Score: 0.483
Data Source: STRINGDB
CYP39A1
Tbio
Family: Enzyme
Novelty: 0.0556276
Score: 0.473
Data Source: STRINGDB
UGT1A5
Tdark
Family: Enzyme
Novelty: 0.04858773
Score: 0.471
Data Source: STRINGDB
PEPD
Tchem
Family: Enzyme
Novelty: 0.00141261
Score: 0.468
Data Source: STRINGDB
NR1I2
Tchem
Family: NR
Novelty: 0.00058969
Score: 0.464
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.02

PubMed score by year
PubTator Score  24.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer