IMPDH1
Inosine-5'-monophosphate dehydrogenase 1
Protein Summary
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
- ENST00000338791
- ENSP00000345096
- ENSG00000106348
- ENST00000348127
- ENSP00000265385
- ENST00000354269
- ENSP00000346219
- ENST00000419067
- ENSP00000399400
- ENST00000480861
- ENSP00000420185
- ENST00000496200
- ENSP00000420803
- IMPD1
- IMPD
- RP10
- IMPD1
- LCA11
- IMPDH-I
- sWSS2608
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.84 | ||
kinase perturbation | 0.76 | ||
disease perturbation | 0.74 | ||
protein domain | 0.73 | ||
co-expressed gene | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.52 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 251 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.52 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 251 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 94
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4