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Tclin
IMPDH1
Inosine-5'-monophosphate dehydrogenase 1

Protein Summary
Description
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338791
  • ENSP00000345096
  • ENSG00000106348
  • ENST00000348127
  • ENSP00000265385
  • ENST00000354269
  • ENSP00000346219
  • ENST00000419067
  • ENSP00000399400
  • ENST00000480861
  • ENSP00000420185
  • ENST00000496200
  • ENSP00000420803

Symbol
  • IMPD1
  • IMPD
  • RP10
  • IMPD1
  • LCA11
  • IMPDH-I
  • sWSS2608
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.84
kinase perturbation
0.76
disease perturbation
0.74
protein domain
0.73
co-expressed gene
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.52   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.52   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4