Tclin IMPDH1 Inosine-5'-monophosphate dehydrogenase 1

Protein Summary

Description

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• P20839
• A4D0Z6
• A4D0Z7
• A6NDW5
• A6NNI6
• B3KNP7
• B3KVM8
• B4DE09
• C9JV30
• J3KNX8
• Q8N194
• Q96NU2
• IMP dehydrogenase 1

Gene Name

• IMPDH1

Ensembl ID

• ENST00000338791
• ENSP00000345096
• ENSG00000106348
• ENST00000348127
• ENSP00000265385
• ENST00000354269
• ENSP00000346219
• ENST00000419067
• ENSP00000399400
• ENST00000480861
• ENSP00000420185
• ENST00000496200
• ENSP00000420803

Symbol

• IMPD1
• IMPD
• RP10
• IMPD1
• LCA11
• IMPDH-I
• sWSS2608

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.84
kinase perturbation	0.76
disease perturbation	0.74
protein domain	0.73
co-expressed gene	0.69

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Inosine-5'-monophosphate Dehydrogenase 1

Protein / Oxidoreductase / Dehydrogenase / Inosine-5'-monophosphate Dehydrogenase 1

Protein / ... / Metalloprotease / Inosine-5'-monophosphate Dehydrogenase 1

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Inosine-5'-monophosphate Dehydrogenase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.52   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 251   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.52   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (4)

Explore Approved Drugs

1 – 4 of 4

thioguanine

IMPDH1Tclin Enzyme

INHIBITOR :

mycophenolic acid

IMPDH1Tclin Enzyme

INHIBITOR pIC50 : 4.7

mycophenolate mofetil

IMPDH1Tclin Enzyme

INHIBITOR pKi : 8.15

ribavirin

IMPDH1Tclin Enzyme

INHIBITOR pIC50 : 6

Active Ligands (94)

Explore Active Ligands

1 – 10 of 94

Mycophenolic 2-(4-pyridyl)-adenosin-5'-yl-methylenebis(phosphonate)

IMPDH1Tclin Enzyme

pKi : 7.85

CHEMBL392203

IMPDH1Tclin Enzyme

pKi : 7.85

CHEMBL1683637

IMPDH1Tclin Enzyme

pKi : 7.85

CHEMBL3098184

IMPDH1Tclin Enzyme

pKi : 7.06

Mycophenolic 2-ethyladenosin-5'-yl-difluoromethylenebis(phosphonate)

IMPDH1Tclin Enzyme

pKi : 7.62

CHEMBL3098187

IMPDH1Tclin Enzyme

pKi : 7.62

CHEMBL409560

IMPDH1Tclin Enzyme

pKi : 7.57

CHEMBL235533

IMPDH1Tclin Enzyme

pKi : 7.31

Tiazofurin-5'-yl-2-ethyladenosin-5'-yl-difluoromethylene bis(phosphonate)

IMPDH1Tclin Enzyme

pKi : 7.52

Mycophenolic 2-trifluoromethyl-adenosin-5'-yl-methylenebis(phosphonate)

IMPDH1Tclin Enzyme

pKi : 7.82

Protein-Protein Interactions (293)

Explore Interacting Targets

1 – 10 of 293

• See Interactions on String-DB

IMPDH2

Tclin

Family:  Enzyme

Novelty:  0.00815361

p_int:  0.999999974

p_ni:  2.6e-8

Score:  0.971

Data Source:  BioPlex,STRINGDB

SMCR8

Tbio

Novelty:  0.11500348

p_int:  0.999998675

p_ni:  0.000001325

Score:  0.483

Data Source:  BioPlex,STRINGDB

WDR25

Tdark

Novelty:  0.53632123

p_int:  0.999998481

p_ni:  5.86e-7

p_wrong:  9.34e-7

Score:  0.189

Data Source:  BioPlex,STRINGDB

SDHC

Tbio

Family:  Enzyme

Novelty:  0.0005776

p_int:  0.999996898

p_ni:  4.4e-8

p_wrong:  0.000003058

Score:  0.24

Data Source:  BioPlex,STRINGDB

ARHGEF39

Tbio

Novelty:  0.30447134

p_int:  0.999991914

p_ni:  0.000006993

p_wrong:  0.000001093

Score:  0.173

Data Source:  BioPlex,STRINGDB

ANKRD9

Tdark

Novelty:  0.43181793

p_int:  0.999991106

p_ni:  0.000002868

p_wrong:  0.000006026

Score:  0.804

Data Source:  BioPlex,STRINGDB

TRIM6

Tbio

Novelty:  0.13070728

p_int:  0.999988223

p_ni:  0.000011772

p_wrong:  6e-9

Score:  0.225

Data Source:  BioPlex,STRINGDB

SLC25A44

Tdark

Family:  Transporter

Novelty:  0.36924538

p_int:  0.99998199

p_ni:  2.93e-7

p_wrong:  0.000017717

Score:  0.525

Data Source:  BioPlex,STRINGDB

MRM2

Tbio

Family:  Enzyme

Novelty:  0.06394065

p_int:  0.999961234

p_ni:  0.000037276

p_wrong:  0.00000149

Score:  0.281

Data Source:  BioPlex,STRINGDB

B3GNTL1

Tdark

Family:  Enzyme

Novelty:  0.13396783

p_int:  0.999955462

p_ni:  1.84e-7

p_wrong:  0.000044354

Score:  0.242

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (17)

Reactome (7)

KEGG (3)

PathwayCommons (4)

UniProt (1)

WikiPathways (2)

Immune System (R-HSA-168256)

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Items per page:

5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of nucleotides	100 targets	R-HSA-15869
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Metabolism	2112 targets	R-HSA-1430728
Metabolism of nucleotides	100 targets	R-HSA-15869
Neutrophil degranulation	543 targets	R-HSA-6798695

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (6)

Components (7)

Processes (5)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
IMP dehydrogenase activity	Inferred from Experiment (EXP)	Reactome
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
nucleic acid binding	Inferred from Direct Assay (IDA)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule
nucleotide binding	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule
RNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pelvic organ prolapse	EFO_0004710	1	1	0	1.3	73.3
educational attainment	EFO_0011015	1	1	1		3.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pelvic organ prolapse	EFO_0004710	0	1.3	73.3
educational attainment	EFO_0011015	1		3.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
CBS domain
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
DNA-binding
GMP biosynthesis
Leber congenital amaurosis

GWAS Trait Find Similar Targets

No Header	No Header
educational attainment
pelvic organ prolapse

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
immune system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	inosine monophosphate dehydrogenase 1	VGNC:14028	463864
Mouse	inosine monophosphate dehydrogenase 1	MGI:96567	23917
Cow	inosine monophosphate dehydrogenase 1	VGNC:30188	504305
Anole lizard	inosine monophosphate dehydrogenase 1		100552361

Species	Name	OMA	EggNOG	Inparanoid
Chimp	inosine monophosphate dehydrogenase 1
Mouse	inosine monophosphate dehydrogenase 1
Cow	inosine monophosphate dehydrogenase 1
Anole lizard	inosine monophosphate dehydrogenase 1

Publication Statistics

PubMed Score 159.52

PubMed score by year

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PubTator Score 90.10

PubTator score by year

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Related Publications

Text Mined References (52)

GeneRif Annotations (31)

Items per page:

10

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PMID	Year	Title