Tclin IMPDH1 Inosine-5'-monophosphate dehydrogenase 1

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Inosine-5'-monophosphate Dehydrogenase 1

Protein / Oxidoreductase / Dehydrogenase / Inosine-5'-monophosphate Dehydrogenase 1

Protein / ... / Metalloprotease / Inosine-5'-monophosphate Dehydrogenase 1

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Inosine-5'-monophosphate Dehydrogenase 1

Protein Summary

Description

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• P20839
• A4D0Z6
• A4D0Z7
• A6NDW5
• A6NNI6
• B3KNP7
• B3KVM8
• B4DE09
• C9JV30
• J3KNX8
• Q8N194
• Q96NU2
• IMP dehydrogenase 1

Gene Name

• IMPDH1

Ensembl ID

• ENST00000338791
• ENSP00000345096
• ENSG00000106348
• ENST00000348127
• ENSP00000265385
• ENST00000354269
• ENSP00000346219
• ENST00000419067
• ENSP00000399400
• ENST00000480861
• ENSP00000420185
• ENST00000496200
• ENSP00000420803

Symbol

• IMPD1
• IMPD
• RP10
• IMPD1
• LCA11
• IMPDH-I
• sWSS2608

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.84
kinase perturbation	0.76
disease perturbation	0.74
protein domain	0.73
co-expressed gene	0.69

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.38   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 251   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.38   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4

Approved Drugs (4)

Explore Approved Drugs

1 – 4 of 4

thioguanine

IMPDH1Tclin Enzyme

INHIBITOR :

mycophenolate mofetil

IMPDH1Tclin Enzyme

INHIBITOR Ki : 7.48148584

mycophenolic acid

IMPDH1Tclin Enzyme

INHIBITOR IC50 : 4.7

ribavirin

IMPDH1Tclin Enzyme

INHIBITOR IC50 : 6

Active Ligands (94)

Explore Active Ligands

1 – 10 of 94

CHEMBL3098176

IMPDH1Tclin Enzyme

Ki : 6.04

CHEMBL162782

IMPDH1Tclin Enzyme

Ki : 6.05

CHEMBL2437269

IMPDH1Tclin Enzyme

Ki : 6.05

CHEMBL3098177

IMPDH1Tclin Enzyme

Ki : 6.06

CHEMBL2437254

IMPDH1Tclin Enzyme

Ki : 6.07

CHEMBL444916

IMPDH1Tclin Enzyme

Ki : 6.09

CHEMBL157617

IMPDH1Tclin Enzyme

IC50 : 6.11

CHEMBL3098164

IMPDH1Tclin Enzyme

Ki : 6.13

CHEMBL2364562

IMPDH1Tclin Enzyme

Ki : 6.96

CHEMBL2418586

IMPDH1Tclin Enzyme

IC50 : 6.17

GWAS Traits (1)

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5

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pelvic organ prolapse	EFO_0004710	1	1	0	1.3	66.8

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pelvic organ prolapse	EFO_0004710	0	1.3	66.8

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Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	inosine monophosphate dehydrogenase 1	VGNC:14028	463864
Mouse	inosine monophosphate dehydrogenase 1	MGI:96567	23917
Cow	inosine monophosphate dehydrogenase 1	VGNC:30188	504305
Anole lizard	inosine monophosphate dehydrogenase 1		100552361

Species	Name	OMA	EggNOG	Inparanoid
Chimp	inosine monophosphate dehydrogenase 1
Mouse	inosine monophosphate dehydrogenase 1
Cow	inosine monophosphate dehydrogenase 1
Anole lizard	inosine monophosphate dehydrogenase 1

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (17)

Reactome (7)

KEGG (3)

PathwayCommons (4)

UniProt (1)

WikiPathways (2)

Immune System (R-HSA-168256)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of nucleotides	100 targets	R-HSA-15869
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Metabolism	2112 targets	R-HSA-1430728
Metabolism of nucleotides	100 targets	R-HSA-15869
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (18)

Functions (6)

Components (7)

Processes (5)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
IMP dehydrogenase activity	Inferred from Experiment (EXP)	Reactome
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
nucleic acid binding	Inferred from Direct Assay (IDA)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule
nucleotide binding	Inferred from Electronic Annotation (IEA)	UniProtKB-UniRule
RNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (293)

Explore Interacting Targets

1 – 10 of 293

• See Interactions on String-DB

IMPDH2

Tclin

Family: Enzyme

Novelty: 0.00815361

p_int: 0.999999974

p_ni: 2.6e-8

Score: 0.971

Data Source: BioPlex,STRINGDB

SMCR8

Tbio

Novelty: 0.11500348

p_int: 0.999998675

p_ni: 0.000001325

Score: 0.483

Data Source: BioPlex,STRINGDB

WDR25

Tdark

Novelty: 0.53632123

p_int: 0.999998481

p_ni: 5.86e-7

p_wrong: 9.34e-7

Score: 0.189

Data Source: BioPlex,STRINGDB

SDHC

Tbio

Family: Enzyme

Novelty: 0.0005776

p_int: 0.999996898

p_ni: 4.4e-8

p_wrong: 0.000003058

Score: 0.24

Data Source: BioPlex,STRINGDB

ARHGEF39

Tdark

Novelty: 0.30447134

p_int: 0.999991914

p_ni: 0.000006993

p_wrong: 0.000001093

Score: 0.173

Data Source: BioPlex,STRINGDB

ANKRD9

Tdark

Novelty: 0.43181793

p_int: 0.999991106

p_ni: 0.000002868

p_wrong: 0.000006026

Score: 0.804

Data Source: BioPlex,STRINGDB

TRIM6

Tbio

Novelty: 0.13070728

p_int: 0.999988223

p_ni: 0.000011772

p_wrong: 6e-9

Score: 0.225

Data Source: BioPlex,STRINGDB

SLC25A44

Tdark

Family: Transporter

Novelty: 0.36924538

p_int: 0.99998199

p_ni: 2.93e-7

p_wrong: 0.000017717

Score: 0.525

Data Source: BioPlex,STRINGDB

MRM2

Tbio

Family: Enzyme

Novelty: 0.06394065

p_int: 0.999961234

p_ni: 0.000037276

p_wrong: 0.00000149

Score: 0.281

Data Source: BioPlex,STRINGDB

B3GNTL1

Tdark

Family: Enzyme

Novelty: 0.13396783

p_int: 0.999955462

p_ni: 1.84e-7

p_wrong: 0.000044354

Score: 0.242

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  131.38

PubMed score by year

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PubTator Score  90.1

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
CBS domain
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
DNA-binding
GMP biosynthesis
Leber congenital amaurosis

GWAS Trait Find Similar Targets

pelvic organ prolapse

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
immune system phenotype
vision/eye phenotype