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Tbio
EFNA1
Ephrin-A1

Protein Summary
Description
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. This gene enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368406
  • ENSP00000357391
  • ENSG00000169242
  • ENST00000368407
  • ENSP00000357392

Symbol
  • EPLG1
  • LERK1
  • TNFAIP4
  • B61
  • EFL1
  • ECKLG
  • EPLG1
  • LERK1
  • LERK-1
  • TNFAIP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
gene perturbation
0.97
virus perturbation
0.96
transcription factor
0.92
PubMedID
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.21   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.21   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
54
electrocardiography
1
1
8
38
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
54
electrocardiography
8
38
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ephrin A1
VGNC:9853
740136
Mouse
MGI:103236
13636
Rat
RGD:620388
94268
Dog
ephrin A1
VGNC:40226
490431
Horse
ephrin A1
VGNC:17447
100063307
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ephrin A1
Mouse
Rat
Dog
ephrin A1
Horse
ephrin A1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20827-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Gene Ontology Terms (33)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (162)
1 – 10 of 162
GAREM1
Tbio
Novelty: 0.21021078
p_int: 0.998250886
p_ni: 0.001711005
p_wrong: 0.000038109
Score: 0.691
Data Source: BioPlex,STRINGDB
EPHA2
Tclin
Family: Kinase
Novelty: 0.00191002
Score: 0.999
Data Source: STRINGDB
EPHA1
Tchem
Family: Kinase
Novelty: 0.00136672
Score: 0.997
Data Source: STRINGDB
EPHA4
Tchem
Family: Kinase
Novelty: 0.00321698
Score: 0.996
Data Source: STRINGDB
EPHA7
Tchem
Family: Kinase
Novelty: 0.01065563
Score: 0.995
Data Source: STRINGDB
EPHA3
Tchem
Family: Kinase
Novelty: 0.00466013
Score: 0.995
Data Source: STRINGDB
EPHB1
Tchem
Family: Kinase
Novelty: 0.01424716
Score: 0.995
Data Source: STRINGDB
EPHA5
Tchem
Family: Kinase
Novelty: 0.01143252
Score: 0.995
Data Source: STRINGDB
EPHA6
Tchem
Family: Kinase
Novelty: 0.02713974
Score: 0.995
Data Source: STRINGDB
EPHA8
Tchem
Family: Kinase
Novelty: 0.02244256
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  141.21

PubMed score by year
PubTator Score  132.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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