Tbio EFNA1 Ephrin-A1

Protein Summary

Description

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P20827
• D3DV86
• Q5SR60
• Q5SR61
• Q6I9T9
• Q8N578

Gene Name

• EFNA1

Ensembl ID

• ENST00000368406
• ENSP00000357391
• ENSG00000169242
• ENST00000368407
• ENSP00000357392

Symbol

• EPLG1
• LERK1
• TNFAIP4
• B61
• EFL1
• ECKLG
• EPLG1
• LERK1
• LERK-1
• TNFAIP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
gene perturbation	0.97
virus perturbation	0.96
transcription factor	0.92
PubMedID	0.9

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Ephrin-a1

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Ephrin Family / Ephrin-a1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.23   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 315   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.23   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0