Tbio EFNA1 Ephrin-A1

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Ephrin-a1

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Ephrin Family / Ephrin-a1

Protein Summary

Description

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P20827
• D3DV86
• Q5SR60
• Q5SR61
• Q6I9T9
• Q8N578

Gene Name

• EFNA1

Ensembl ID

• ENST00000368406
• ENSP00000357391
• ENSG00000169242
• ENST00000368407
• ENSP00000357392

Symbol

• EPLG1
• LERK1
• TNFAIP4
• B61
• EFL1
• ECKLG
• EPLG1
• LERK1
• LERK-1
• TNFAIP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
gene perturbation	0.97
virus perturbation	0.96
transcription factor	0.92
PubMedID	0.9

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.91   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 315   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.91   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (49)

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1 – 5 of 49

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	3	6	5	3.7	99.1
urate measurement	EFO_0004531	6	8	12		99
serum urea measurement	EFO_0009795	2	5	5		98.1
cancer antigen 15.3 measurement	EFO_0010585	1	2	2		93.8
gastric carcinoma	EFO_0000178	3	3	0	1.3	93.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	5	3.7	99.1
urate measurement	EFO_0004531	12		99
serum urea measurement	EFO_0009795	5		98.1
cancer antigen 15.3 measurement	EFO_0010585	2		93.8
gastric carcinoma	EFO_0000178	0	1.3	93.3

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ephrin A1	VGNC:9853	740136
Mouse	ephrin A1	MGI:103236	13636
Rat	ephrin A1	RGD:620388	94268
Dog	ephrin A1	VGNC:40226	490431
Horse	ephrin A1	VGNC:17447	100063307

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ephrin A1
Mouse	ephrin A1
Rat	ephrin A1
Dog	ephrin A1
Horse	ephrin A1

Protein Structure (3 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20827-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (20)

Reactome (4)

KEGG (6)

PathwayCommons (5)

WikiPathways (5)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665

Gene Ontology Terms (33)

Functions (2)

Components (3)

Processes (28)

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1 – 2 of 2

GO Term	Evidence	Assigned by
ephrin receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
signaling receptor binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (162)

Explore Interacting Targets

1 – 10 of 162

• See Interactions on String-DB

GAREM1

Tbio

Novelty:  0.21021078

p_int:  0.998250886

p_ni:  0.001711005

p_wrong:  0.000038109

Score:  0.691

Data Source:  BioPlex,STRINGDB

EPHA2

Tclin

Family:  Kinase

Novelty:  0.00191002

Score:  0.999

Data Source:  STRINGDB

EPHA1

Tchem

Family:  Kinase

Novelty:  0.00136672

Score:  0.997

Data Source:  STRINGDB

EPHA4

Tchem

Family:  Kinase

Novelty:  0.00321698

Score:  0.996

Data Source:  STRINGDB

EPHA7

Tchem

Family:  Kinase

Novelty:  0.01065563

Score:  0.995

Data Source:  STRINGDB

EPHA3

Tchem

Family:  Kinase

Novelty:  0.00466013

Score:  0.995

Data Source:  STRINGDB

EPHB1

Tchem

Family:  Kinase

Novelty:  0.01424716

Score:  0.995

Data Source:  STRINGDB

EPHA5

Tchem

Family:  Kinase

Novelty:  0.01143252

Score:  0.995

Data Source:  STRINGDB

EPHA6

Tchem

Family:  Kinase

Novelty:  0.02713974

Score:  0.995

Data Source:  STRINGDB

EPHA8

Tchem

Family:  Kinase

Novelty:  0.02244256

Score:  0.995

Data Source:  STRINGDB

Publication Statistics

PubMed Score  145.91

PubMed score by year

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PubTator Score  132.53

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

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3D-structure
Alternative splicing
Angiogenesis
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
GPI-anchor
Lipoprotein

GWAS Trait Find Similar Targets

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1,5 anhydroglucitol measurement
age at onset
albuminuria
allergy
appendicular lean mass
aspartate aminotransferase measurement
biological sex
blood urea nitrogen measurement
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cardiovascular system phenotype
muscle phenotype
neoplasm
skeleton phenotype