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Tbio
EFNA1
Ephrin-A1

Protein Summary
Description
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. This gene enco ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368406
  • ENSP00000357391
  • ENSG00000169242
  • ENST00000368407
  • ENSP00000357392

Symbol
  • EPLG1
  • LERK1
  • TNFAIP4
  • B61
  • EFL1
  • ECKLG
  • EPLG1
  • LERK1
  • LERK-1
  • TNFAIP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
gene perturbation
0.97
virus perturbation
0.96
transcription factor
0.92
PubMedID
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.9   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.9   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Gene Ontology Terms (33)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (162)
1 – 10 of 162
GAREM1
Tbio
Novelty: 0.19252808
p_int: 0.998250886
p_ni: 0.001711005
p_wrong: 0.000038109
Score: 0.691
Data Source: BioPlex,STRINGDB
EPHA2
Tclin
Family: Kinase
Novelty: 0.00179986
Score: 0.999
Data Source: STRINGDB
EPHA1
Tchem
Family: Kinase
Novelty: 0.00080325
Score: 0.997
Data Source: STRINGDB
EPHA4
Tchem
Family: Kinase
Novelty: 0.00137701
Score: 0.996
Data Source: STRINGDB
EPHA7
Tchem
Family: Kinase
Novelty: 0.01421837
Score: 0.995
Data Source: STRINGDB
EPHA3
Tchem
Family: Kinase
Novelty: 0.00370563
Score: 0.995
Data Source: STRINGDB
EPHB1
Tchem
Family: Kinase
Novelty: 0.01647449
Score: 0.995
Data Source: STRINGDB
EPHA5
Tchem
Family: Kinase
Novelty: 0.00477017
Score: 0.995
Data Source: STRINGDB
EPHA6
Tchem
Family: Kinase
Novelty: 0.03085318
Score: 0.995
Data Source: STRINGDB
EPHA8
Tchem
Family: Kinase
Novelty: 0.01776839
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  132.90

PubMed score by year
PubTator Score  132.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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