Protein Classes
Protein Summary
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. This gene enco ...more
- ENST00000368406
- ENSP00000357391
- ENSG00000169242
- ENST00000368407
- ENSP00000357392
- EPLG1
- LERK1
- TNFAIP4
- B61
- EFL1
- ECKLG
- EPLG1
- LERK1
- LERK-1
- TNFAIP4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.97 | ||
gene perturbation | 0.97 | ||
virus perturbation | 0.96 | ||
transcription factor | 0.92 | ||
PubMedID | 0.9 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.21 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 315 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.21 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 315 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 54 | |||||
electrocardiography | 1 | 1 | 8 | 38 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 54 | |||||
electrocardiography | 8 | 38 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ephrin A1 | VGNC:9853 | 740136 | |||||
Mouse | MGI:103236 | 13636 | ||||||
Rat | RGD:620388 | 94268 | ||||||
Dog | ephrin A1 | VGNC:40226 | 490431 | |||||
Horse | ephrin A1 | VGNC:17447 | 100063307 | |||||
Protein Structure (3 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (20)
Reactome (4)
KEGG (6)
PathwayCommons (5)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Gene Ontology Terms (33)
Functions (2)
Components (3)
Processes (28)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (162)
1 – 10 of 162
GAREM1
Novelty: 0.21021078
p_int: 0.998250886
p_ni: 0.001711005
p_wrong: 0.000038109
Score: 0.691
Data Source: BioPlex,STRINGDB
EPHA2
Family: Kinase
Novelty: 0.00191002
Score: 0.999
Data Source: STRINGDB
EPHA1
Family: Kinase
Novelty: 0.00136672
Score: 0.997
Data Source: STRINGDB
EPHA4
Family: Kinase
Novelty: 0.00321698
Score: 0.996
Data Source: STRINGDB
EPHA7
Family: Kinase
Novelty: 0.01065563
Score: 0.995
Data Source: STRINGDB
EPHA3
Family: Kinase
Novelty: 0.00466013
Score: 0.995
Data Source: STRINGDB
EPHB1
Family: Kinase
Novelty: 0.01424716
Score: 0.995
Data Source: STRINGDB
EPHA5
Family: Kinase
Novelty: 0.01143252
Score: 0.995
Data Source: STRINGDB
EPHA6
Family: Kinase
Novelty: 0.02713974
Score: 0.995
Data Source: STRINGDB
EPHA8
Family: Kinase
Novelty: 0.02244256
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score 141.21
PubMed score by year
PubTator Score 132.53
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword