Protein Summary
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple ...more
- ENST00000222982
- ENSP00000222982
- ENSG00000106258
- ENST00000439761
- ENSP00000401269
- ENST00000646887
- ENSP00000496704
- CP35
- PCN3
- CYPIIIA5
- P450PCN3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
biological term | 0.97 | ||
chemical | 0.97 | ||
transcription factor perturbation | 0.84 | ||
cell type or tissue | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1076.82 (req: < 5)
Gene RIFs: 367 (req: <= 3)
Antibodies: 190 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1076.82 (req: >= 5)
Gene RIFs: 367 (req: > 3)
Antibodies: 190 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (8)
Protein-Protein Interactions (122)
CYP3A7
Family: Enzyme
Novelty: 0.00736888
p_int: 0.999999926
p_wrong: 7.5e-8
Score: 0.969
Data Source: BioPlex,STRINGDB
SERPINB4
Novelty: 0.00522283
p_int: 0.989963871
p_ni: 0.010036129
Score: 0.222
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (85)
Reactome (6)
KEGG (6)
PathwayCommons (1)
WikiPathways (72)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aflatoxin activation and detoxification | ||||
Reactome | Biological oxidations | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Metabolism | ||||
Reactome | Phase I - Functionalization of compounds | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aflatoxin activation and detoxification | ||||
Biological oxidations | ||||
Cytochrome P450 - arranged by substrate type | ||||
Metabolism | ||||
Phase I - Functionalization of compounds | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (7)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
tacrolimus measurement | 2 | 3 | 5 | 97.3 | |||||
blood metabolite measurement | 2 | 3 | 3 | 95.9 | |||||
serum metabolite measurement | 1 | 3 | 3 | 92.9 | |||||
testosterone measurement | 6 | 2 | 6 | 90.1 | |||||
sex hormone-binding globulin measurement | 6 | 2 | 6 | 75.7 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
tacrolimus measurement | 5 | 97.3 | |||||
blood metabolite measurement | 3 | 95.9 | |||||
serum metabolite measurement | 3 | 92.9 | |||||
testosterone measurement | 6 | 90.1 | |||||
sex hormone-binding globulin measurement | 6 | 75.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 3 subfamily A member 5 | VGNC:7372 | 737374 | |||||
Mouse | MGI:88610 | 13113 | ||||||
Rat | RGD:708392 | 171352 | ||||||
Dog | cytochrome P450 3A26 | 415127 | ||||||
Horse | cytochrome p450 3A95 | 100067109 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 3 subfamily A member 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytochrome P450 3A26 | |||||
Horse | cytochrome p450 3A95 | |||||
Publication Statistics
PubMed Score 1076.82
PubMed score by year
PubTator Score 914.97
PubTator score by year
Related Publications
Text Mined References (659)
GeneRif Annotations (367)
Items per page:
0 of 0
PMID | Year | Title |
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