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Tclin
CYP3A5
Cytochrome P450 3A5

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222982
  • ENSP00000222982
  • ENSG00000106258
  • ENST00000439761
  • ENSP00000401269
  • ENST00000646887
  • ENSP00000496704

Symbol
  • CP35
  • PCN3
  • CYPIIIA5
  • P450PCN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
biological term
0.97
chemical
0.97
transcription factor perturbation
0.84
cell type or tissue
0.76


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1041.28   (req: < 5)
View Publications
Gene RIFs: 367   (req: <= 3)
View Gene RIFs
Antibodies: 190   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1041.28   (req: >= 5)
Gene RIFs: 367   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Explore Approved Drugs
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
kidney transplant
EFO_0010134
1
2
3
95.7
tacrolimus measurement
EFO_0008458
1
2
3
95.7
chronic kidney disease
EFO_0003884
1
1
1
75.9
urinary metabolite measurement
EFO_0005116
1
1
1
75.9
neutrophil count
EFO_0004833
1
1
1
39.7
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
kidney transplant
EFO_0010134
3
95.7
tacrolimus measurement
EFO_0008458
3
95.7
chronic kidney disease
EFO_0003884
1
75.9
urinary metabolite measurement
EFO_0005116
1
75.9
neutrophil count
EFO_0004833
1
39.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (85)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
20 targets
R-HSA-5423646
Reactome
Biological oxidations
221 targets
R-HSA-211859
Reactome
Cytochrome P450 - arranged by substrate type
65 targets
R-HSA-211897
Reactome
Metabolism
2112 targets
R-HSA-1430728
Reactome
Phase I - Functionalization of compounds
105 targets
R-HSA-211945
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
20 targets
R-HSA-5423646
Biological oxidations
221 targets
R-HSA-211859
Cytochrome P450 - arranged by substrate type
65 targets
R-HSA-211897
Metabolism
2112 targets
R-HSA-1430728
Phase I - Functionalization of compounds
105 targets
R-HSA-211945
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
estrogen 16-alpha-hydroxylase activity
Inferred from Direct Assay (IDA)
BHF-UCL
oxidoreductase activity
Inferred from Direct Assay (IDA)
BHF-UCL
monooxygenase activity
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
oxygen binding
Traceable Author Statement (TAS)
ProtInc
aromatase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
heme binding
Inferred from Electronic Annotation (IEA)
InterPro
iron ion binding
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (122)
1 – 10 of 122
CYP3A7
Tclin
Family: Enzyme
Novelty: 0.00736888
p_int: 0.999999926
p_wrong: 7.5e-8
Score: 0.969
Data Source: BioPlex,STRINGDB
IGHG2
Tdark
p_int: 0.99256231
p_ni: 0.007435176
p_wrong: 0.000002514
Data Source: BioPlex
SERPINB4
Tbio
Novelty: 0.00522283
p_int: 0.989963871
p_ni: 0.010036129
Score: 0.222
Data Source: BioPlex,STRINGDB
IGHG1
Tdark
p_int: 0.955216659
p_ni: 0.044783341
p_wrong: 1e-9
Data Source: BioPlex
CYP2C9
Tchem
Novelty: 0.00041914
Score: 0.948
Data Source: STRINGDB
EPHX1
Tchem
Family: Enzyme
Novelty: 0.00220169
Score: 0.947
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.946
Data Source: STRINGDB
CYP2C19
Tchem
Novelty: 0.000394
Score: 0.946
Data Source: STRINGDB
CYP1A2
Tchem
Novelty: 0.00034756
Score: 0.945
Data Source: STRINGDB
CYP2B6
Tchem
Novelty: 0.00018351
Score: 0.944
Data Source: STRINGDB
Publication Statistics
PubMed Score  1041.28

PubMed score by year
PubTator Score  914.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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