You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CYP2B6
Cytochrome P450 2B6

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase. This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324071
  • ENSP00000324648
  • ENSG00000197408
  • ENST00000643956
  • ENSP00000495579

Symbol
  • CPB6
  • EFVM
  • IIB1
  • P450
  • CYP2B
  • CYP2B7
  • CYP2B7P
  • CYPIIB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug
1
biological term
0.92
disease
0.75
molecular function
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5506.32   (req: < 5)
Gene RIFs: 211   (req: <= 3)
Antibodies: 315   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5506.32   (req: >= 5)
Gene RIFs: 211   (req: > 3)
Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Active Ligands (1)
1 – 1 of 1
thiotepa
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
DDT metabolite measurement
1
2
2
92.5
gestational serum measurement
2
1
2
58
organochlorine pesticide measurement
1
1
1
56.1
polybrominated biphenyl measurement
1
1
1
28.3
polybrominated diphenyl ether measurement
1
1
1
28.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
DDT metabolite measurement
2
92.5
gestational serum measurement
2
58
organochlorine pesticide measurement
1
56.1
polybrominated biphenyl measurement
1
28.3
polybrominated diphenyl ether measurement
1
28.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450, family 2, subfamily B, polypeptide 6
678687
Mouse
MGI:107303
13090
Rat
RGD:2466
24300
Dog
cytochrome P450 2B11
474177
Horse
cytochrome P450 2B11-like
100068603
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450, family 2, subfamily B, polypeptide 6
Mouse
Rat
Dog
cytochrome P450 2B11
Horse
cytochrome P450 2B11-like
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (85)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
CYP2E1 reactions
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Fatty acids
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
CYP2E1 reactions
Cytochrome P450 - arranged by substrate type
Fatty acids
Metabolism
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (209)
1 – 10 of 209
ATP2B3
Tbio
Family: Transporter
Novelty: 0.00901493
p_int: 0.999012815
p_ni: 0.000987185
Score: 0.807
Data Source: BioPlex,STRINGDB
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.997183862
p_ni: 0.002816138
Score: 0.534
Data Source: BioPlex,STRINGDB
ATP2B4
Tbio
Family: Transporter
Novelty: 0.00560356
p_int: 0.989228158
p_ni: 0.010771842
Score: 0.646
Data Source: BioPlex,STRINGDB
DHRS4
Tbio
Family: Enzyme
Novelty: 0.02992279
p_int: 0.889049698
p_ni: 0.110603856
p_wrong: 0.000346445
Score: 0.223
Data Source: BioPlex,STRINGDB
EPHX1
Tchem
Family: Enzyme
Novelty: 0.00220169
Score: 0.972
Data Source: STRINGDB
AOX1
Tbio
Family: Enzyme
Novelty: 0.0025823
Score: 0.95
Data Source: STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.948
Data Source: STRINGDB
SULT2A1
Tbio
Family: Enzyme
Novelty: 0.00475549
Score: 0.947
Data Source: STRINGDB
CYP3A5
Tclin
Family: Enzyme
Novelty: 0.00105607
Score: 0.944
Data Source: STRINGDB
CYP4A11
Tbio
Novelty: 0.01121493
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  5506.32

PubMed score by year
PubTator Score  1960.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: