Tbio CAST Calpastatin

Protein Summary

Description

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P20810
• B7Z468
• G5E946
• G5E9D3
• O95360
• Q05DE8
• Q7Z4K0
• Q96D08
• Q9H1Z5

Gene Name

• CAST

Ensembl ID

• ENST00000309190
• ENSP00000312523
• ENSG00000153113
• ENST00000338252
• ENSP00000343421
• ENST00000341926
• ENSP00000339914
• ENST00000395812
• ENSP00000379157
• ENST00000395813
• ENSP00000379158
• ENST00000508830
• ENSP00000425721
• ENST00000510756
• ENSP00000422176

Symbol

• BS-17
• PLACK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor perturbation	0.97
disease perturbation	0.93
transcription factor	0.91
trait	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1124.74   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 367   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1124.74   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 367   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0