Protein Summary
Calcium-regulated non-lysosomal thiol-protease. Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
- ENST00000337571
- ENSP00000336840
- ENSG00000092529
- ENST00000349748
- ENSP00000183936
- ENST00000356316
- ENSP00000348667
- ENST00000357568
- ENSP00000350181
- ENST00000397163
- ENSP00000380349
- ENST00000397200
- ENSP00000380384
- ENST00000397204
- ENSP00000380387
- ENST00000569136
- ENSP00000455254
- CANP3
- CANPL3
- NCL1
- p94
- CANP3
- LGMD2
- nCL-1
- CANPL3
- LGMD2A
- LGMDD4
- LGMDR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
protein domain | 0.99 | ||
molecular function | 0.88 | ||
disease perturbation | 0.87 | ||
cellular component | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 365.66 (req: < 5)
Gene RIFs: 98 (req: <= 3)
Antibodies: 166 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 365.66 (req: >= 5)
Gene RIFs: 98 (req: > 3)
Antibodies: 166 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0