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Tbio
CAPN3
Calpain-3

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease. Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337571
  • ENSP00000336840
  • ENSG00000092529
  • ENST00000349748
  • ENSP00000183936
  • ENST00000356316
  • ENSP00000348667
  • ENST00000357568
  • ENSP00000350181
  • ENST00000397163
  • ENSP00000380349
  • ENST00000397200
  • ENSP00000380384
  • ENST00000397204
  • ENSP00000380387
  • ENST00000569136
  • ENSP00000455254

Symbol
  • CANP3
  • CANPL3
  • NCL1
  • p94
  • CANP3
  • LGMD2
  • nCL-1
  • CANPL3
  • LGMD2A
  • LGMDD4
  • LGMDR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
protein domain
0.99
molecular function
0.88
disease perturbation
0.87
cellular component
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.66   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.66   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0