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Tbio
CAPN3
Calpain-3

Protein Summary
Description
Calcium-regulated non-lysosomal thiol-protease. Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337571
  • ENSP00000336840
  • ENSG00000092529
  • ENST00000349748
  • ENSP00000183936
  • ENST00000356316
  • ENSP00000348667
  • ENST00000357568
  • ENSP00000350181
  • ENST00000397163
  • ENSP00000380349
  • ENST00000397200
  • ENSP00000380384
  • ENST00000397204
  • ENSP00000380387
  • ENST00000569136
  • ENSP00000455254

Symbol
  • CANP3
  • CANPL3
  • NCL1
  • p94
  • CANP3
  • LGMD2
  • nCL-1
  • CANPL3
  • LGMD2A
  • LGMDD4
  • LGMDR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
protein domain
0.99
molecular function
0.88
disease perturbation
0.87
cellular component
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.73   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.73   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Gene Ontology Terms (48)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (98)
1 – 10 of 98
CAST
Tbio
Novelty: 0.00077213
Score: 0.943
Data Source: STRINGDB
CAPNS1
Tbio
Novelty: 0.00108655
Score: 0.911
Data Source: STRINGDB
DYSF
Tbio
Novelty: 0.0026878
Score: 0.909
Data Source: STRINGDB
CAPNS2
Tbio
Novelty: 1.32806324
Score: 0.908
Data Source: STRINGDB
TTN
Tbio
Family: Kinase
Novelty: 0.00054314
Score: 0.84
Data Source: STRINGDB
TRIM71
Tbio
Family: Enzyme
Novelty: 0.01727233
Score: 0.712
Data Source: STRINGDB
TRIM32
Tbio
Family: Enzyme
Novelty: 0.01320808
Score: 0.692
Data Source: STRINGDB
MYOT
Tbio
Novelty: 0.01053217
Score: 0.682
Data Source: STRINGDB
LAMA2
Tbio
Novelty: 0.00237711
Score: 0.67
Data Source: STRINGDB
FKRP
Tbio
Novelty: 0.00912199
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  330.73

PubMed score by year
PubTator Score  293.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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