Tbio EDN2 Endothelin-2

Protein Summary

Description

Endothelins are endothelium-derived vasoconstrictor peptides. This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P20800
• Q5T1R3
• ET-2

Gene Name

• EDN2

Ensembl ID

• ENST00000372587
• ENSP00000361668
• ENSG00000127129

Symbol

• ET2
• ET-2
• PPET2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
gene perturbation	0.93
PubMedID	0.86
transcription factor perturbation	0.68
phenotype	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Endothelin-2

DTO Classes

Protein / Signaling / Hormone / Endothelin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 513.78   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 513.78   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0