Protein Summary
Endothelins are endothelium-derived vasoconstrictor peptides. This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
- ENST00000372587
- ENSP00000361668
- ENSG00000127129
- ET2
- ET-2
- PPET2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.95 | ||
gene perturbation | 0.93 | ||
PubMedID | 0.86 | ||
transcription factor perturbation | 0.68 | ||
phenotype | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 447.99 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 171 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 447.99 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 171 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (177)
Nearest Tclin Targets
Pathways (21)
Reactome (7)
KEGG (4)
PathwayCommons (9)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (2)
Components (3)
Processes (25)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 2 | 2 | 1 | 6 | 54.1 | ||||
heel bone mineral density | 1 | 1 | 1 | 47.7 | |||||
mathematical ability | 2 | 1 | 2 | 13.5 | |||||
balding measurement | 1 | 1 | 1 | 10.1 | |||||
systolic blood pressure | 1 | 1 | 1 | 8.1 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 1 | 6 | 54.1 | ||||
heel bone mineral density | 1 | 47.7 | |||||
mathematical ability | 2 | 13.5 | |||||
balding measurement | 1 | 10.1 | |||||
systolic blood pressure | 1 | 8.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | endothelin 2 | VGNC:527 | 469298 | |||||
Macaque | endothelin 2 | 695960 | ||||||
Mouse | MGI:95284 | 13615 | ||||||
Rat | RGD:2533 | 24324 | ||||||
Dog | endothelin 2 | VGNC:40200 | 403508 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | endothelin 2 | |||||
Macaque | endothelin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | endothelin 2 | |||||
Publication Statistics
PubMed Score 447.99
PubMed score by year
PubTator Score 266.22
PubTator score by year
Related Publications
Text Mined References (67)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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