Protein Classes
Protein Summary
Endothelins are endothelium-derived vasoconstrictor peptides. This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
- ENST00000372587
- ENSP00000361668
- ENSG00000127129
- ET2
- ET-2
- PPET2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.95 | ||
gene perturbation | 0.93 | ||
PubMedID | 0.86 | ||
transcription factor perturbation | 0.68 | ||
phenotype | 0.64 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 447.99 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 171 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 447.99 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 171 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 2 | 2 | 1 | 6 | 54.1 | ||||
heel bone mineral density | 1 | 1 | 1 | 47.7 | |||||
mathematical ability | 2 | 1 | 2 | 13.5 | |||||
balding measurement | 1 | 1 | 1 | 10.1 | |||||
systolic blood pressure | 1 | 1 | 1 | 8.1 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 1 | 6 | 54.1 | ||||
heel bone mineral density | 1 | 47.7 | |||||
mathematical ability | 2 | 13.5 | |||||
balding measurement | 1 | 10.1 | |||||
systolic blood pressure | 1 | 8.1 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | endothelin 2 | VGNC:527 | 469298 | |||||
Macaque | endothelin 2 | 695960 | ||||||
Mouse | MGI:95284 | 13615 | ||||||
Rat | RGD:2533 | 24324 | ||||||
Dog | endothelin 2 | VGNC:40200 | 403508 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | endothelin 2 | |||||
Macaque | endothelin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | endothelin 2 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (21)
Reactome (7)
KEGG (4)
PathwayCommons (9)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 7
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Gene Ontology Terms (30)
Functions (2)
Components (3)
Processes (25)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (177)
1 – 10 of 177
EDNRB
Family: GPCR
Novelty: 0.00053875
Score: 0.986
Data Source: Reactome,STRINGDB
EDN1
Novelty: 0.00007453
Score: 0.983
Data Source: STRINGDB
EDNRA
Family: GPCR
Novelty: 0.00045591
Score: 0.979
Data Source: Reactome,STRINGDB
AGTR1
Family: GPCR
Novelty: 0.00033439
Score: 0.962
Data Source: STRINGDB
MCHR1
Family: GPCR
Novelty: 0.00295097
Score: 0.953
Data Source: STRINGDB
AGTR2
Family: GPCR
Novelty: 0.00064774
Score: 0.945
Data Source: STRINGDB
ADRA1D
Family: GPCR
Novelty: 0.00203304
Score: 0.945
Data Source: STRINGDB
AVPR1B
Family: GPCR
Novelty: 0.00774309
Score: 0.944
Data Source: STRINGDB
AVPR1A
Family: GPCR
Novelty: 0.00305957
Score: 0.941
Data Source: STRINGDB
ADRA1B
Family: GPCR
Novelty: 0.00381271
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score 447.99
PubMed score by year
PubTator Score 266.22
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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GWAS Trait
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