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Tbio
EDN2
Endothelin-2

Protein Summary
Description
Endothelins are endothelium-derived vasoconstrictor peptides. This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372587
  • ENSP00000361668
  • ENSG00000127129

Symbol
  • ET2
  • ET-2
  • PPET2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
gene perturbation
0.93
PubMedID
0.86
transcription factor perturbation
0.68
phenotype
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 447.99   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 447.99   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
Score:  0.986
Data Source:  Reactome,STRINGDB
EDN1
Tbio
Novelty:  0.00007453
Score:  0.983
Data Source:  STRINGDB
EDNRA
Tclin
Family:  GPCR
Novelty:  0.00045591
Score:  0.979
Data Source:  Reactome,STRINGDB
AGTR1
Tclin
Family:  GPCR
Novelty:  0.00033439
Score:  0.962
Data Source:  STRINGDB
MCHR1
Tchem
Family:  GPCR
Novelty:  0.00295097
Score:  0.953
Data Source:  STRINGDB
AGTR2
Tchem
Family:  GPCR
Novelty:  0.00064774
Score:  0.945
Data Source:  STRINGDB
ADRA1D
Tclin
Family:  GPCR
Novelty:  0.00203304
Score:  0.945
Data Source:  STRINGDB
AVPR1B
Tclin
Family:  GPCR
Novelty:  0.00774309
Score:  0.944
Data Source:  STRINGDB
AVPR1A
Tclin
Family:  GPCR
Novelty:  0.00305957
Score:  0.941
Data Source:  STRINGDB
ADRA1B
Tclin
Family:  GPCR
Novelty:  0.00381271
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
2
1
6
54.1
heel bone mineral density
1
1
1
47.7
mathematical ability
2
1
2
13.5
balding measurement
1
1
1
10.1
systolic blood pressure
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6
54.1
heel bone mineral density
1
47.7
mathematical ability
2
13.5
balding measurement
1
10.1
systolic blood pressure
1
8.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelin 2
VGNC:527
469298
Macaque
endothelin 2
695960
Mouse
MGI:95284
13615
Rat
RGD:2533
24324
Dog
endothelin 2
VGNC:40200
403508
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelin 2
Macaque
endothelin 2
Mouse
Rat
Dog
endothelin 2
Publication Statistics
PubMed Score 447.99
PubMed score by year
PubTator Score 266.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title