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Tbio
NTF3
Neurotrophin-3

Protein Summary
Description
Seems to promote the survival of visceral and proprioceptive sensory neurons. The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331010
  • ENSP00000328738
  • ENSG00000185652
  • ENST00000423158
  • ENSP00000397297

Symbol
  • NT3
  • HDNF
  • NGF2
  • NT-3
  • NGF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.97
biological term
0.77
disease
0.77
chemical
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1132.79   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1132.79   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia
1
1
0
3.1
32.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
insomnia
0
3.1
32.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurotrophin 3
VGNC:13333
466931
Macaque
neurotrophin 3
721988
Mouse
MGI:97380
18205
Rat
RGD:619728
81737
Dog
neurotrophin 3
VGNC:44002
486731
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurotrophin 3
Macaque
neurotrophin 3
Mouse
Rat
Dog
neurotrophin 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P20783-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (64)
Activated NTRK3 signals through PI3K (R-HSA-9603381)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK3 signals through PI3K
Reactome
Activated NTRK3 signals through PLCG1
Reactome
Activated NTRK3 signals through RAS
Reactome
NTF3 activates NTRK2 (TRKB) signaling
Reactome
NTF3 activates NTRK3 signaling
Name
Explore in Pharos
Explore in Source
Activated NTRK3 signals through PI3K
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through RAS
NTF3 activates NTRK2 (TRKB) signaling
NTF3 activates NTRK3 signaling
Protein-Protein Interactions (199)
1 – 10 of 199
KCTD18
Tdark
Novelty: 0.8176728
p_int: 0.999607417
p_ni: 0.000004662
p_wrong: 0.000387921
Data Source: BioPlex
MAD2L1BP
Tbio
Novelty: 0.48374717
p_int: 0.983134945
p_ni: 0.000349583
p_wrong: 0.016515472
Score: 0.519
Data Source: BioPlex,STRINGDB
METTL5
Tbio
Family: Enzyme
Novelty: 0.17532142
p_int: 0.976928626
p_ni: 1.4e-8
p_wrong: 0.02307136
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.973868514
p_ni: 0.026131486
Data Source: BioPlex
PYGB
Tbio
Family: Enzyme
Novelty: 0.00224148
p_int: 0.899326478
p_ni: 0.100673522
Score: 0.201
Data Source: BioPlex,STRINGDB
PYGL
Tchem
Family: Enzyme
Novelty: 0.01157477
p_int: 0.831239695
p_ni: 0.168760306
Score: 0.519
Data Source: BioPlex,STRINGDB
NTRK3
Tclin
Family: Kinase
Novelty: 0.00177321
Score: 0.998
Data Source: Reactome,STRINGDB
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.997
Data Source: Reactome,STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.996
Data Source: STRINGDB
NGFR
Tclin
Novelty: 0.00072052
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  1132.79

PubMed score by year
PubTator Score  548.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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