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Tbio
OGN
Mimecan

Protein Summary
Description
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262551
  • ENSP00000262551
  • ENSG00000106809
  • ENST00000375561
  • ENSP00000364711

Symbol
  • OIF
  • SLRR3A
  • OG
  • OIF
  • SLRR3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
cellular component
0.77
gene perturbation
0.67
small molecule perturbation
0.65
PubMedID
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1042.64   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1042.64   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
56
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
osteoglycin
VGNC:4816
739901
Macaque
osteoglycin
706168
Mouse
MGI:109278
18295
Dog
osteoglycin
VGNC:44110
610704
Horse
osteoglycin
VGNC:21018
100054772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
osteoglycin
Macaque
osteoglycin
Mouse
Dog
osteoglycin
Horse
osteoglycin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P20774-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Reactome
Defective CHST6 causes MCDC1
Reactome
Defective ST3GAL3 causes MCT12 and EIEE15
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (80)
1 – 10 of 80
ASB7
Tdark
Novelty:  0.21883348
p_int:  0.999999999
p_ni:  1e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.979408474
p_ni:  0.020591526
Score:  0.189
Data Source:  BioPlex,STRINGDB
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.978535949
p_ni:  0.021464051
Score:  0.653
Data Source:  BioPlex,STRINGDB
OMD
Tbio
Novelty:  0.01992089
Score:  0.964
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.943
Data Source:  STRINGDB
LUM
Tbio
Novelty:  0.00219939
Score:  0.942
Data Source:  STRINGDB
FMOD
Tbio
Novelty:  0.00459438
Score:  0.935
Data Source:  STRINGDB
PRELP
Tbio
Novelty:  0.02849334
Score:  0.935
Data Source:  STRINGDB
KERA
Tbio
Novelty:  0.00789599
Score:  0.933
Data Source:  STRINGDB
CHST5
Tbio
Family:  Enzyme
Novelty:  0.10903299
Score:  0.917
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1042.64

PubMed score by year
PubTator Score  414.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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