Tbio OGN Mimecan

Protein Summary

Description

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P20774
• Q6FIB0
• Q9UF90
• Q9UNK5

Gene Name

• OGN

Ensembl ID

• ENST00000262551
• ENSP00000262551
• ENSG00000106809
• ENST00000375561
• ENSP00000364711

Symbol

• OIF
• SLRR3A
• OG
• OIF
• SLRR3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.93
cellular component	0.77
gene perturbation	0.67
small molecule perturbation	0.65
PubMedID	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1195.34   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 283   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1195.34   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0