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Tbio
GZMH
Granzyme H

Protein Summary
Description
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216338
  • ENSP00000216338
  • ENSG00000100450
  • ENST00000382548
  • ENSP00000371988

Symbol
  • CGL2
  • CTSGL2
  • CCP-X
  • CGL-2
  • CSP-C
  • CTLA1
  • CTSGL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.76
protein domain
0.58
PubMedID
0.55
cell line
0.49
gene perturbation
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.9   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.9   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (38)
1 – 10 of 38
AGT
Tbio
Novelty: 0.00049613
Score: 0.909
Data Source: STRINGDB
IGFBP3
Tchem
Novelty: 0.0003776
Score: 0.907
Data Source: STRINGDB
IGFALS
Tbio
Novelty: 0.0287658
Score: 0.907
Data Source: STRINGDB
IGF2
Tbio
Novelty: 0.00021277
Score: 0.9
Data Source: STRINGDB
IGF1
Tbio
Novelty: 0.00003878
Score: 0.9
Data Source: STRINGDB
GNLY
Tbio
Novelty: 0.00183877
Score: 0.885
Data Source: STRINGDB
PRF1
Tchem
Novelty: 0.0002835
Score: 0.88
Data Source: STRINGDB
NKG7
Tdark
Novelty: 0.0599879
Score: 0.877
Data Source: STRINGDB
GZMA
Tbio
Family: Enzyme
Novelty: 0.00322362
Score: 0.842
Data Source: STRINGDB
GZMB
Tchem
Family: Enzyme
Novelty: 0.00052869
Score: 0.836
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.90

PubMed score by year
PubTator Score  39.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer