Tbio GZMH Granzyme H

Protein Summary

Description

Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P20718
• G3V2C5
• Q6XGZ0
• Q6XGZ1

Gene Name

• GZMH

Ensembl ID

• ENST00000216338
• ENSP00000216338
• ENSG00000100450
• ENST00000382548
• ENSP00000371988

Symbol

• CGL2
• CTSGL2
• CCP-X
• CGL-2
• CSP-C
• CTLA1
• CTSGL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.76
protein domain	0.58
PubMedID	0.55
cell line	0.49
gene perturbation	0.49

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Granzyme H

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Granzyme H

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.06   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.06   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0