DDC
Aromatic-L-amino-acid decarboxylase
Protein Summary
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
- ENST00000357936
- ENSP00000350616
- ENSG00000132437
- ENST00000380984
- ENSP00000370371
- ENST00000426377
- ENSP00000395069
- ENST00000431062
- ENSP00000399184
- ENST00000444124
- ENSP00000403644
- ENST00000615193
- ENSP00000484104
- AADC
- AADC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.88 | ||
transcription factor perturbation | 0.88 | ||
protein domain | 0.85 | ||
disease | 0.81 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 868.85 (req: < 5)
Gene RIFs: 91 (req: <= 3)
Antibodies: 481 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 868.85 (req: >= 5)
Gene RIFs: 91 (req: > 3)
Antibodies: 481 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1