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Tclin
DDC
Aromatic-L-amino-acid decarboxylase

Protein Summary
Description
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357936
  • ENSP00000350616
  • ENSG00000132437
  • ENST00000380984
  • ENSP00000370371
  • ENST00000426377
  • ENSP00000395069
  • ENST00000431062
  • ENSP00000399184
  • ENST00000444124
  • ENSP00000403644
  • ENST00000615193
  • ENSP00000484104

Symbol
  • AADC
  • AADC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
transcription factor perturbation
0.88
protein domain
0.85
disease
0.81
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.64   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 782.64   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
carbidopa
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
94.4
2
2
2
72.4
blood metabolite measurement
1
1
1
67.2
lymphocyte count
1
1
1
51.9
1
1
0
1.3
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
94.4
2
72.4
blood metabolite measurement
1
67.2
lymphocyte count
1
51.9
0
1.3
34.8
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (36)
Catecholamine biosynthesis (R-HSA-209905)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Catecholamine biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Serotonin and melatonin biosynthesis
Name
Explore in Pharos
Explore in Source
Catecholamine biosynthesis
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Serotonin and melatonin biosynthesis
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (115)
1 – 10 of 115
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.994
Data Source: STRINGDB
DBH
Tchem
Family: Enzyme
Novelty: 0.00074741
Score: 0.989
Data Source: STRINGDB
TPH1
Tclin
Family: Enzyme
Novelty: 0.00098637
Score: 0.985
Data Source: STRINGDB
MAOB
Tclin
Family: Enzyme
Novelty: 0.00030366
Score: 0.981
Data Source: STRINGDB
COMT
Tclin
Family: Enzyme
Novelty: 0.00025107
Score: 0.979
Data Source: STRINGDB
PAH
Tclin
Family: Enzyme
Novelty: 0.00337068
Score: 0.971
Data Source: STRINGDB
TPH2
Tchem
Family: Enzyme
Novelty: 0.00265377
Score: 0.969
Data Source: STRINGDB
MAOA
Tclin
Family: Enzyme
Novelty: 0.00031037
Score: 0.968
Data Source: STRINGDB
AOC1
Tchem
Family: Enzyme
Novelty: 0.00146464
Score: 0.964
Data Source: STRINGDB
AANAT
Tbio
Family: Enzyme
Novelty: 0.0039709
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  782.64

PubMed score by year
PubTator Score  627.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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